常染色体显性遗传性多囊肾病肾移植临床技术操作规范(2022版)  

Clinical technical operation specification of kidney transplantation for autosomal dominant polycystic kidney disease(2022 edition)

作　　者：中华医学会器官移植学分会 王强[2] 朱一辰[3] 田野 Branch of Organ Transplantation of Chinese Medical Association;Tian Ye(不详;Peking University People’s Hospital,Beijing 100044,China)

机构地区：[1]不详 [2]北京大学人民医院,北京100044 [3]首都医科大学附属北京友谊医院

出　　处：《器官移植》2023年第1期24-30,共7页Organ Transplantation

基　　金：国家自然科学基金(82070765);医学免疫学国家重点实验室开放课题(NKMI2020K05);蛋白质组学国家重点实验室开放课题(SKLPO202009)。

摘　　要：常染色体显性遗传性多囊肾病(ADPKD)是最常见的遗传性肾病,也是终末期肾病(ESRD)的最常见原因之一。肾移植是ADPKD伴ESRD患者的最佳肾脏替代治疗方式,目前国内外学者对于ADPKD患者肾移植前多囊肾是否需要切除存在一定的争议,并且多囊肾切除手术标准及手术方式也不尽相同。为进一步规范ADPKD患者肾移植的临床技术操作,中华医学会器官移植学分会组织器官移植学专家从ADPKD的诊断、ADPKD肾移植的适应证和禁忌证、术前评估及处理、多囊肾切除术、术后管理等方面,制定本规范。Autosomal dominant polycystic kidney disease(ADPKD)is the most common inherited kidney disease and one of the most common causes for end-stage renal disease(ESRD).Kidney transplantation is the optimal renal replacement therapy for ADPKD patients complicated with ESRD.Currently,scholars at home and abroad have a certain controversy about whether polycystic kidney resection is necessary in ADPKD patients before kidney transplantation,and the criteria and methods for polycystic nephrectomy also differ.To further standardize the clinical technical operation of kidney transplantation in ADPKD patients,experts in organ transplantation organized by Branch of Organ Transplantation of Chinese Medical Association formulated this specification from the aspects of diagnosis of ADPKD,indications and contraindications of kidney transplantation for ADPKD,preoperative evaluation and treatment,polycystic nephrectomy,and postoperative management,etc.

关 键 词：常染色体显性遗传性多囊肾病 基因突变 肾移植 多囊肾切除 二代测序 终末期肾病(ESRD) 血液透析 肾脏囊肿 

分 类 号：R617[医药卫生—外科学] R692[医药卫生—临床医学]