右美托咪定对肺癌根治术单肺通气患者炎症因子及应激反应的影响  

Effects of Dexmedetomidine on inflammatory factors and stress response in patients with one lung ventilation after radical resection of lung cancer

作　　者：梁磊 袁晚秋 曾进福 彭洪[1] LIANG Lei;YUAN Wanqiu;ZENG Jinfu;PENG Hong(Department of Anesthesiology,Pingxiang People's Hospital,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡市人民医院麻醉科,江西萍乡337000

出　　处：《中国当代医药》2022年第36期124-127,共4页China Modern Medicine

基　　金：江西省萍乡市科技计划项目(2021PY046)。

摘　　要：目的 探讨右美托咪定(DEX)对肺癌根治术单肺通气(OLV)患者炎症因子及应激反应的影响。方法 选取2021年9月至2022年2月萍乡市人民医院收治的60例接受肺癌根治术治疗的肺癌患者作为研究对象,按照随机数字表法将其分为研究组和对照组,各30例。研究组采用DEX,对照组输注等量生理盐水。比较两组患者OLV开始前即刻(T0)、OLV结束前即刻(T1)、术后1 h(T2)炎症因子水平[降钙素原(PCT)、C反应蛋白(CRP)]、应激反应[皮质醇(Cor)、血糖(Glu)、心率(HR)、平均动脉压(MAP)]。结果 随着时间的延长,两组患者PCT、CRP水平呈逐渐升高趋势,差异有统计学意义(P<0.05);两组患者T0时PCT、CRP水平比较,差异无统计学意义(P>0.05);两组患者T1、T2时点PCT、CRP水平均高于本组T0时,差异有统计学意义(P<0.05);研究组T1、T2时的PCT、CRP水平低于对照组,差异有统计学意义(P<0.05)。随着时间的延长,两组患者Cor、Glu、HR、MAP水平呈逐渐升高趋势,差异有统计学意义(P<0.05);两组患者T0时Cor、Glu、HR、MAP水平比较,差异无统计学意义(P>0.05);两组患者T1、T2时点Cor、Glu、HR、MAP水平均高于本组T0时,差异有统计学意义(P<0.05);研究组T1、T2时点Cor、Glu、HR、MAP水平低于对照组,差异有统计学意义(P<0.05)。结论 DEX可降低肺癌根治术OLV患者炎症因子水平,缓解患者应激反应。Objective To investigate the effect of Dexmedetomidine(DEX) on inflammatory factors and stress response in patients with one lung ventilation(OLV) after radical resection of lung cancer. Methods From September 2021 to February2022, 60 patients with lung cancer treated by radical resection in Pingxiang People’s Hospital were selected as research objects, they were divided into study group and control group according to the random number table method, with 30 cases in each group. DEX was used in the study group, and the same amount of normal saline was infused in the control group. The levels of inflammatory factors(procalcitonin [PCT], C-reactive protein [CRP]), stress response(cortisol [Cor], blood glucose[Glu], heart rate [HR] and mean arterial pressure [MAP]) were compared between the two groups immediately before the start of OLV(T0), immediately before the end of OLV(T1), 1 h after operation(T2). Results There were no significant differences in the levels of PCT and CRP between the two groups at T0(P>0.05). The levels of PCT and CRP at T1and T2in the two groups were higher than those at T0, and the differences were statistically significant(P<0.05). The levels of PCT and CRP in the study group at T1and T2were lower than those in the control group, and the differences were statistically significant(P<0.05). There were no significant differences in the levels of Cor, Glu, HR and MAP between the two groups at T0(P>0.05).The levels of Cor, Glu, HR and MAP at T1and T2in the two groups were higher than those at T0, and the differences were statistically significant(P<0.05). The levels of Cor, Glu, HR and MAP at T1, T2in the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). Conclusion DEX can reduce the level of inflammatory factors and alleviate the stress response of patients with OLV after radical resection of lung cancer.

关 键 词：肺癌根治术 单肺通气 右美托咪定 炎症因子 应激反应 

分 类 号：R734.2[医药卫生—肿瘤]