盐酸右美托咪定对行宫颈癌腹腔镜下根治术患者应激反应、血流动力学和术后恢复的影响  

Effect of Dexmedetomidine Hydrochloride on stress response, hemodynamics and postoperative recovery in patients undergoing laparoscopic radical surgery for cervical cancer

作　　者：陈鹏 CHEN Peng(Department of Anesthesiology,Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Jiangsu Province,Suzhou215000,China)

机构地区：[1]上海交通大学医学院附属苏州九龙医院麻醉科,江苏苏州215000

出　　处：《中国当代医药》2022年第36期128-131,共4页China Modern Medicine

摘　　要：目的 探讨盐酸右美托咪定对行宫颈癌腹腔镜根治术患者应激反应、血流动力学和术后恢复的影响。方法选取2018年9月至2021年12月上海交通大学医学院附属苏州九龙医院收治的60例行宫颈癌腹腔镜根治术患者作为研究对象,按照抽签法分为右美托咪定组(30例)与对照组(30例),右美托咪定组采用盐酸右美托咪定进行麻醉诱导,对照组采用以等剂量的生理盐水代替。比较两组患者的应激反应、血流动力学和术后恢复情况。结果 两组患者的平均动脉压(MAP)、心率(HR)时间、组间、交互作用比较,差异无统计学意义(P>0.05)。右美托咪定组的术后定向恢复时间、拔管时间、睁眼时间、自主呼吸恢复时间短于对照组,差异有统计学意义(P<0.05)。两组患者血清P物质的时间、组间、交互作用比较,差异有统计学意义(P<0.05)。右美托咪定组术后7 d的不良反应总发生率为6.7%,低于对照组的27.7%,差异有统计学意义(P<0.05)。结论 盐酸右美托咪定在宫颈癌腹腔镜根治术患者的应用能抑制血清应激反应指标P物质的释放,可促进术后康复,减少术后不良反应,且不会引起血流动力学的波动。Objective To investigate the effect of Dexmedetomidine Hydrochloride on stress response, hemodynamics and postoperative recovery in patients undergoing laparoscopic radical surgery for cervical cancer. Methods A total of 60patients undergoing laparoscopic radical surgery for cervical cancer admitted to Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University School of Medicine from September 2018 to December 2021 were selected as the research subjects, they were divided into Dexmedetomidine group(30 cases) and control group(30 cases) according to the drawing lot method. The Dexmedetomidine group was treated with Dexmedetomidine Hydrochloride for induction of anesthesia, and the control group was replaced with an equal dose of normal saline. The stress response, hemodynamics and postoperative recovery were compared between the two groups. Results There were no significant differences of time, inter group and interaction between the two groups in mean arterial pressure(MAP), heart rate(HR)(P>0.05). The postoperative directional recovery time, extubation time, eye opening time, and spontaneous breathing recovery time in the Dexmedetomidine group were shorter than those in the matched group, the differences were statistically significant(P<0.05). There were significant differences of time, inter group and interaction between the two groups in substance P in serum(P <0.05). The total incidence of adverse reactions was 6.7% in Dexmedetomidine group, which was lower than 27.7% in matched group, the difference was statistically significant(P <0.05). Conclusion The application of Dexmedetomidine Hydrochloride in patients undergoing laparoscopic radical surgery for cervical cancer can inhibit the release of serum stress response index substance P without causing hemodynamic fluctuations, and can also reduce the occurring of postoperative adverse reactions,thereby promoting postoperative recovery of the patients.

关 键 词：右美托咪定 宫颈癌 腹腔镜根治术 P物质 血流动力学 不良反应 

分 类 号：R737.33[医药卫生—肿瘤]