Neuroprotective Nanoscavenger Induces Coaggregation of β-Amyloid and Facilitates Its Clearance in Alzheimer’s Disease Brain  

作　　者：Yu Zhao Yu Jiang Jingshan Chai Fan Huang Zhanzhan Zhang Qi Liu Zhuo Yang Yang Liu Linqi Shi 

机构地区：[1]Key Laboratory of Functional Polymer Materials of Ministry of Education,College of Chemistry,Nankai University,Tianjin 300071 [2]State Key Laboratory of Medicinal Chemical Biology,Nankai University,Tianjin 300071 [3]Key Laboratory of Bioactive for Materials Ministry of Education,School of Medicine,Nankai University,Tianjin 300071 [4]Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192

出　　处：《CCS Chemistry》2021年第8期2321-2335,共15页中国化学会会刊（英文）

基　　金：supported by the National Key Research and Development Programs of China(grant no.2018YFA0209700);the National Natural Science Foundation of China(NSFC;grant nos.51673100 and 21620102005);the Fundamental Research Funds for the Central Universities(Nankai University;grant nos.ZB19100123 and ZB16008705);the Tianjin Natural Science Foundation(grant no.18JCQNJC03600);the China Postdoctoral Science Foundation(grant no.2019M660975).

摘　　要：The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.

关 键 词：solubleβ-amyloid aggregates nanoscavengers cross the BBB coaggregate microglial clearance 

分 类 号：R749[医药卫生—神经病学与精神病学]