肝病降脂颗粒对非酒精性脂肪肝患者肝脏生化及血脂水平的影响  

Effect of Ganbing Jiangzhi Granules on Liver Biochemistry and Blood Lipid Levels in Patients with Nonalcoholic Fatty Liver Disease

作　　者：秦莉[1] 邱秀霞 QIN Li;QIU Xiu-xia(Department of Traditional Chinese Medicine,Tianjin First Hospital,Tianjin 300232,China;Department of Gastroenterology,Tianjin First Hospital,Tianjin 300232,China)

机构地区：[1]天津市第一医院中医科,天津300232 [2]天津市第一医院消化科,天津300232

出　　处：《医学信息》2022年第21期65-68,共4页Journal of Medical Information

摘　　要：目的 研究肝病降脂颗粒对非酒精性脂肪肝(NAFLD)患者肝脏生化及血脂水平的影响。方法 选取2020年3月-2021年3月我院收治的70例NAFLD患者,通过随机数字表法分为对照组与观察组,各35例。对照组给予多烯磷脂酰胆碱治疗,观察组在对照组基础上给予肝病降脂颗粒治疗,比较两组临床疗效、中医证候积分、体质量(BMI)、肝脏生化指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)]、血脂水平[总胆固醇(TC)、甘油三酯(TG)]。结果 观察组治疗总有效率为88.57%,高于对照组的80.00%,差异有统计学意义(P<0.05)。两组治疗后中医证候积分及BMI低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组治疗后ALT、AST、GGT水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组治疗后TC、TG水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论 肝病降脂颗粒在NAFLD治疗中具有确切疗效,可缓解临床症状,减轻患者体重,改善肝脏生化指标,恢复血脂紊乱。Objective To study the effect of Ganbing Jiangzhi granules on liver biochemistry and blood lipid levels in patients with nonalcoholic fatty liver disease(NAFLD).Methods Seventy patients with NAFLD admitted to our hospital from March 2020 to March 2021 were selected and divided into control group and observation group by random number table method, with 35 cases in each group. The control group was treated with polyene phosphatidylcholine, and the observation group was treated with Ganbing Jiangzhi granules on the basis of the control group. The clinical efficacy,TCM syndrome score, body mass(BMI), liver biochemical indexes [alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamyl transpeptidase(GGT)] and blood lipid levels [total cholesterol(TC), triglyceride(TG)] were compared between the two groups. Results The total effective rate of treatment in the observation group was 88.57%, which was higher than 80.00% in the control group, and the difference was statistically significant(P<0.05). After treatment, the scores of TCM syndromes and BMI in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant( P<0.05). After treatment, the levels of ALT, AST and GGT in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant(P<0.05). The levels of TC and TG in the two groups after treatment were lower than those before treatment, and those in the observation group was lower than those in the control group, the differences were statistically significant( P<0.05).Conclusion Ganbing Jiangzhi granules has definite curative effect in the treatment of NAFLD, which can relieve clinical symptoms, reduce body weight, improve liver biochemical indexes and restore dyslipidemia.

关 键 词：非酒精性脂肪肝 肝病降脂颗粒 肝脏生化指标 血脂水平 

分 类 号：R575.5[医药卫生—消化系统]