点阵CO_(2)激光与Q开关1064 nm掺钕钇铝石榴石晶体(Nd∶YAG)激光治疗睑黄瘤的效果  

Efficacy of fractional CO_(2) laser and 1064-nm,Q-switched Nd∶YAG laser on xanthelasma palpebrarum

作　　者：黄悦[1] 袁瑾 赵小燕[1] 周昆丽 李桂琼 张启国[1] 屠秀顾 蔡良奇[1] Huang Yue;Yuan Jin;Zhao Xiaoyan;Zhou Kunli;Li Guiqiong;Zhang Qiguo;Tu Xiugu;Cai Liangqi(Department of Dermatology,the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University/The School of Clinical Medicine,Fujian Medical University,Xiamen 361002,China)

机构地区：[1]厦门大学附属第一医院皮肤科,厦门大学医学院福建医科大学临床医学部,厦门361002

出　　处：《中华医学美学美容杂志》2022年第6期463-466,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨点阵CO_(2)激光与Q开关1064 nm Nd∶YAG激光治疗睑黄瘤的疗效和安全性。方法2020年10月至2021年10月,厦门大学附属第一医院皮肤科门诊收治双侧睑黄瘤患者30例,男5例、女25例;年龄38~67(51±7)岁。随机选取一侧皮损用剥脱性CO_(2)点阵激光治疗为点阵组,另一侧用Q开关1064 nm Nd∶YAG激光治疗为Q开关组。两组均每28 d治疗1次共4次。治疗前和最后1次治疗后1个月,进行大体照片拍摄比较效果;皮肤超声测量治疗前后瘤体厚度差异;记录局部瘢痕、炎症后色素沉着或者色素减退等不良反应的发生率。结果两组患者治疗前后大体照片疗效评分比较,差异有统计学意义(Z=-3.08,P<0.05)。皮肤超声下瘤体厚度比较,两组治疗前后比较,差异有统计学意义(t=21.60,P<0.05;t=17.29,P<0.05);两组治疗前比较,差异无统计学意义(t=0.46,P=0.650);两组治疗后比较,差异有统计学意义(t=8.41,P<0.001)。两组均无严重不良反应。结论点阵CO_(2)激光或者Q开关1064 nm Nd∶YAG激光均可安全有效地改善睑黄疣,其中点阵CO_(2)激光临床效果更好。Objective To determine the clinical efficacy and safety of a fractional CO_(2) laser and a 1064 nm,Q-switched Nd∶YAG laser therapy in the treatment of xanthelasma palpebrarum.Methods From October 2020 to October 2021,30 patients(5 males and 25 females)with bilateralxanthelasma palpebrarum of the eyelid were enrolled in the Department of Dermatology,the First Affiliated Hospital of Xiamen University.The age ranged from 38 to 67(51±7)years.One side was randomly treated with fractional CO_(2) laser as the fractional group,and the other side was treated with Q-switch 1064 nm Nd∶YAG laser as the Q-switch group.The treatment was given every 28 days for 4 times.Before treatment and 1 month after the last treatment,the general pictures were taken to compare the clinical effect.Skin ultrasound was used to measure the difference of tumor thickness before and after treatment.The incidence of adverse reactions,such as local scar,hyperpigmentation or hypopigmentation after inflammation,were recorded.Results Under general photos,there was statistically significant difference in efficacy scores between the two groups before and after treatment(Z=-3.082,P<0.05).By comparison of tumor thickness under skin ultrasound,the difference between the two groups before and after treatment was statistically significant(t=21.60,P<0.05;t=17.29,P<0.05);there was no statistically significant difference between the two groups before treatment(t=0.46,P=0.650),but there was statistically significant difference between the two groups after treatment(t=8.41,P<0.001).No serious adverse reactions occurred in both groups.Conclusions Fractional CO_(2) laser or Q-switch 1064 nm Nd∶YAG laser can safely and effectively improve xanthelasma palpebrarum,in which the effect of fractional CO_(2) laser is much better.

关 键 词：眼睑肿瘤 治疗结果 睑黄瘤 半面对照试验 超脉冲CO_(2)激光 Q开关1064 nm Nd∶YAG激光 

分 类 号：R739.71[医药卫生—肿瘤]