PRKAA1/AMPKα1在消化系肿瘤中的研究进展  

Research progress of PRKAA1/AMPKα1 in digestive system tumors

作　　者：雍桃 刘杰[1] 魏秋亚 樊勇[1] YONG Tao;LIU Jie;WEI Qiuya;FAN Yong(Fourth Ward of General Surgery Department,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院普通外科四病区,甘肃兰州730030

出　　处：《中国肿瘤外科杂志》2022年第6期615-620,共6页Chinese Journal of Surgical Oncology

基　　金：甘肃省重点研发计划(20YF3FA033)。

摘　　要：AMP依赖的蛋白激酶(AMPK)是一种细胞能量状态的感受器,其调控异常与肿瘤的发生发展密切相关。PRKAA1是AMPK的催化亚基-α亚基,其磷酸化在AMPK活化过程中起重要作用。恶性肿瘤的发生发展离不开细胞能量,AMPK随着细胞内特定的能量条件变化,发挥着抑肿瘤或促肿瘤的双重作用。该文将重点讨论PRKAA1基因在肿瘤进展中的功能及其在消化道肿瘤作用机制中的研究进展,探究其在不同消化系统恶性肿瘤调控网络中的地位和作用,为消化系统肿瘤的诊断和治疗提供新的思路。AMP-dependent protein kinase(AMPK)is a cellular energy state receptor whose abnormal regulation is closely related to tumor development.The phosphorylation of PRKAA1 which is the catalytic subunit-αsubunit of AMPK,plays an important role in AMPK activation.The development of malignant tumors is inseparable from cellular energy.And AMPK plays a dual role in both of tumor suppression and promotion in response to specific changes in intracellular energy conditions.In this paper,the function of PRKAA 1 gene in tumor progression and its research progress in the mechanism of action of GI tumors will be introduced,in order to explore its role in the regulatory network of different GI malignancies.

关 键 词：PRKAA1 AMPKα1 消化系肿瘤 治疗 预后 

分 类 号：R735[医药卫生—肿瘤]