双侧原发性乳腺癌超声显像特征与癌组织中ER、PR表达的相关性及预后分析  

Correlation of Ultrasonographic Features of Bilateral Primary Breast Cancer with ER and PR Expression in Cancer Tissue and Prognostic Analysis

作　　者：王伟 胡林巧 吴斌 何山 李焰 李燕茹 张艳珍 郑轲 Wang Wei;Hu Linqiao;Wu Bin(Southwest Medical University,Luzhou,Sichuan 646000;Department of Breast and Thyroid Surgery,Yibin Second People s Hospital,Yibin,Sichuan 644000;Department of Breast Surgery,Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China.)

机构地区：[1]西南医科大学,四川泸州646000 [2]宜宾第二人民医院乳腺甲状腺外科,四川宜宾644000 [3]西南医科大学附属医院乳腺外科,四川泸州646000

出　　处：《四川医学》2022年第12期1214-1221,共8页Sichuan Medical Journal

基　　金：宜宾市第二人民医院院内导师项目课题(编号:2021OS17)。

摘　　要：目的探究双侧原发性乳腺癌组织ER、PR表达与超声显像特征相关性,分析患者预后特点。方法回顾性选取2010年1月至2022年3月我院乳腺甲状腺外科收治的37例女性双侧原发性乳腺癌患者病理及超声资料,比较两侧乳腺癌病理特征及超声显像特征的差异性,分析乳腺癌超声显像特征与同侧乳腺癌ER、PR表达的关系,分析预后特点。结果在浸润性乳腺癌患者中,第二癌肿块血供不丰富组较血供丰富组有更高的ER阳性表达率((P<0.05),腋窝淋巴结无转移组较转移组有更高的ER、PR阳性表达率(P<0.05)。第一癌与第二癌在肿块内部回声、瘤内钙化、瘤内血供方面差异有统计学意义(P<0.05)。同时性与异时性双乳癌生存率无明显差异(P>0.05);双侧腋窝淋巴结转移组较无转移组及单侧转移组无病生存率低(P<0.05),双侧病灶ER、PR一致阴性患者预后最差,ER、PR一致阳性患者预后最好(P<0.05),双侧pTNM高分期(Ⅲ期)较双侧低分期及单侧高分期预后更差(P<0.05)。结论双侧原发性乳腺癌患者两侧浸润性癌灶在超声显像上有一定的差异性。在浸润性乳腺癌患者中,第二癌瘤内血供、腋窝淋巴结转移在一定程度上可以反映ER、PR的表达情况。双侧浸润性乳腺癌患者腋窝淋巴结转移可能面临更高局部复发及远处转移风险,预后不良,术后需密切随访监测。Objective To investigate the correlation between ER and PR expression of bilateral primary breast cancer tissues and ultrasound imaging features and to analyze the prognostic characteristics of patients.Methods We retrospectively selected pathological and ultrasound data of 37 female patients with bilateral primary breast cancer who were admitted to our breast and thyroid surgery department from January 2010 to March 2022,comparing the differences in pathological features and ultrasound imaging features of both sides of breast cancer,analyzing the relationship between ultrasound imaging features of breast cancer and ER and PR expression of ipsilateral breast cancer,and the prognostic characteristics.Results In patients with invasive breast cancer,the group with a non-rich blood supply to the second cancer mass had a higher ER positive expression rate than that of the group with a rich blood supply((P<0.05),and the group with no metastasis in axillary lymph nodes had a higher ER and PR positive expression rate than that of the group with metastasis((P<0.05).There were differences between the first and second cancer in terms of internal echogenicity of the mass,intratumoral calcification,and intratumoral blood supply((P<0.05).There was no significant difference in the survival rate between simultaneous and heterochronic bilateral breast cancer(P>0.05);the disease-free survival rate was lower in the bilateral axillary lymph node metastasis group than that in the no metastasis group and the unilateral metastasis group(P<0.05),and the prognosis was worst in patients with unanimously negative ER and PR bilateral lesions and best in patients with unanimously positive ER and PR(P<0.05),and the prognosis was worse in bilateral pTNM high stage(stage Ⅲ)than that in bilateral low stage,the prognosis of patients with bilateral high pTNM stage(stage Ⅲ)was worse than that of patients with bilateral low stage and unilateral high stage(P<0.05).Conclusion There are some differences in the ultrasound imaging of invasive cancer

关 键 词：双侧原发性乳腺癌 ER PR 超声 预后 

分 类 号：R737.9[医药卫生—肿瘤]