基于微流控与喷墨打印技术的微液滴形成芯片  

Micro-droplet formation chip based on microfluidic andinkjet printing technology

作　　者：单子龙 祝明杰[1,2] 宁伟 吴炫烨 SHAN Zilong;ZHU Mingjie;NING Wei;WU Xuanye(School of Microelectronics,Shanghai University,Shanghai 200000,China;Shanghai IndustrialμTechnology Research Institute,Shanghai 200000,China)

机构地区：[1]上海大学微电子学院,上海200000 [2]上海微技术工业研究院,上海200000

出　　处：《传感器与微系统》2023年第1期26-29,共4页Transducer and Microsystem Technologies

摘　　要：基于微流控的液滴发生是数字聚合酶链式反应(PCR)等分子生物学检测数字化的基础。研究了一种新的微流控法制备微液滴,采用微流控与热泡喷墨技术结合的方法制备微液滴。利用热泡喷墨打印技术的液滴发生原理,本文提出了一种能够在1 s内形成超过300000个皮升(pL)级液滴的创新型方法。针对这种新的液滴发生方法,本文系统研究了喷孔位置、分散相黏度、分散相与MEMS半导体芯片的接触角等因素对液滴生成的影响。该技术在数字PCR等分子生物学检测领域有巨大的应用潜力。Micro-droplet generation based on microfluidics enables the digitization of molecular biology test methods such as digital PCR.A new microfluidic method is studied to generate micro-droplet,that combines microfluidic channel with thermal bubble inkjet printing technology to generate micro-droplet.By using the droplet generation principe of thermal bubble inkjet printing technology,an innovation-type method is proposed to generate more than 300000 droplets at the scale of picolitre(pL)in one second.Aiming at this new method of droplet generation,the work systematically studies the effect of nozzle location,dispersed solution viscosity and the contact angle between dispersed phase and MEMS semiconductor chip on micro droplet generation.The technology shows the potential for application in molecular biological detection fields such as digital PCR.

关 键 词：微流控 微液滴 微机电系统技术 喷墨打印技术 

分 类 号：R197.39[医药卫生—卫生事业管理]