牙龈卟啉单胞菌临床菌株致病作用的研究进展  

Research progress on the pathogenicity of Porphyromonas gingivalis clinical strains

作　　者：吴雅洁 李雨庆[2] 周芳洁 李继遥[1] WU Yajie;LI Yuqing;ZHOU Fangjie;LI Jiyao(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Dis-eases&Department of Operative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Dis-eases&West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科,四川成都610041 [2]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院,四川成都610041

出　　处：《口腔疾病防治》2023年第5期365-369,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(81991501)。

摘　　要：牙龈卟啉单胞菌与牙周炎发生发展密切相关,被认为是导致牙槽骨吸收的重要致病菌之一。现阶段对于牙龈卟啉单胞菌的研究多采用ATCC 33277等遗传学特性得到确认和保证并可追溯的实验室标准菌株。临床上提取到的分离菌株的毒力表型(内毒素、菌毛等)与标准菌株具有较多差异,对宿主致病作用和致病能力也具有广泛差异。另外,牙龈卟啉单胞菌被认为和多种全身疾病具有相关性,不同菌株的毒力特点、致病能力等会对全身疾病产生不同影响。然而,现阶段对临床菌株与标准菌株的研究十分匮乏,也缺乏对于两种来源细菌的系统比较。本文对近5~10年牙龈卟啉单胞菌临床分离菌株与标准菌株之间毒力表型和致病作用的差异等进行综述,旨在阐明牙龈卟啉单胞菌基因序列中的重要毒力基因位点,对治疗方法的改进和相关药物的研制有重要作用。Porphyromonas gingivalis(P. gingivalis) is closely related to the occurrence and development of periodontitis. It is considered to be one of the important pathogens leading to alveolar bone resorption. At present, research on P.gingivalis mostly adopts standard laboratory strains whose genetic characteristics have been confirmed, are guaranteed and are traceable, such as ATCC 33277. The virulence phenotypes(endotoxin, firmbria, etc.) of clinically extracted isolates are quite different from those of standard strains, and the pathogenic effects and ability of the host are also widely different. In addition, P. gingivalis is considered to have a significant correlation with a variety of systemic diseases, and the virulence characteristics and pathogenic ability of different strains will have different effects on systemic diseases.However, at present, there is a lack of research on clinical strains and standard strains, and there is a lack of systematic comparison between the two sources of bacteria. In this paper, the differences in the virulence phenotypes and pathogenic effects between clinical isolates and standard strains of P. gingivalis in the last 5-10 years are reviewed. The aim is to elucidate the important virulence gene loci in the P. gingivalis gene sequence, which will play an important role in improving therapeutic methods and the development of related drugs.

关 键 词：牙周炎 牙龈卟啉单胞菌 临床菌株 标准菌株 菌毛 荚膜 脂多糖 牙龈素 

分 类 号：R78[医药卫生—口腔医学]