锶离子改性钛种植体表面研究进展  

Research progress on surface modification of titanium implants by strontium ions

作　　者：姜小维 石安源 郭丽 顾春宁 秦海燕 JIANG Xiaowei;SHI Any-uan;GUO Li;GU Chunning;QIN Haiyan(Department of Dental Implantology,Nanjing Stomatological Hospital,Medical School,Nanjing University,Nanjing 210008,China;Department of Stomatology,Affiliated Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院,南京市口腔医院种植科,江苏南京210008 [2]南京大学医学院附属鼓楼医院,南京鼓楼医院口腔科,江苏南京210008

出　　处：《口腔疾病防治》2023年第5期375-380,共6页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：江苏省重点研发计划(社会发展)项目(BE2019622);南京市卫生科技发展专项资金(YKK18122)。

摘　　要：传统钛种植体缺乏生物活性,不能完全满足临床要求。锶离子对钛种植体表面改性可以增强其骨结合能力,减少种植体周围炎的发生。本文就锶离子改性钛种植体表面的生物性能进行综述。目前研究表明,锶离子可以通过水热处理、电化学沉积、磷酸盐化学转化、火焰喷涂、超分子自组装、磁控溅射、激光沉积和碱腐蚀等方法添加到种植体表面。锶离子改性的钛种植体表面能促进成骨、增强早期骨结合、抑制细菌生长、减少术后感染;当锶离子与其他元素如银、锌、镓、钙等掺杂时,具有更好的骨结合和抗菌效果。但关于锶离子改性钛种植体表面的研究大多为动物实验和体外实验,观察时间与种植体实际使用寿命相比较短,所得结论可能与实际临床应用有所差别,长期效果有待研究;此外,各种改性方法之间的成骨效果也需要进一步比较。未来的研究可以关注以下几点:(1)寻找高效的,可以广泛临床应用的改性方法;(2)研究如何控制种植体附近的锶离子浓度,在发挥其生物学功能的同时,减少毒副作用;(3)进行长期随访的临床实验以观察其成骨及抗菌效果。Traditional titanium implants do not completely meet the clinical requirements because they are bioinert.The surface of titanium implants, modified by strontium ions, can enhance osseointegration and reduce peri-implantitis.In this paper, the biological properties of titanium implant surfaces modified by strontium ions were reviewed. Strontium ions can be coated on the implant surface by hydrothermal treatment, electrochemical deposition, phosphate chemical conversion, flame-spraying, supramolecular self-assembly, magnetron sputtering, laser deposition and alkali etching. Implant surfaces modified by strontium ions can not only promote osteogenesis and early osseointegration but also inhibit bacterial growth and reduce postoperative infections. Even better osseointegration and antibacterial effects can be achieved when strontium ions are incorporated with other elements, such as silver, zinc, gallium, and calcium. However,most of the studies on the use of strontium ion-modified titanium implants are animal experiments and in vitro experiments, and the observation time is short compared with the actual service life of the implants. Thus, the conclusions obtained may be different from the actual clinical application, and the long-term effects need to be studied. In addition,the osteogenic effects of various modification methods also need to be compared. Future research can focus on the following points:(1) to find efficient modification methods that can be widely used in the clinic;(2)to study how to controlthe concentration of strontium ions near the implant to exert their biological function and reduce their toxic side effects;and(3) to conduct long-term follow-up clinical trials to observe their osteogenic and antibacterial effects.

关 键 词：锶离子 钛 种植体 成骨性能 表面改性 抗菌性能 银离子 锌离子 水热处理 电化学沉积 

分 类 号：R78[医药卫生—口腔医学]