Livin、STAT3基因在海南地区甲状腺癌组织中的表达情况  

Expression of Livin and STAT3 genes in thyroid cancer tissues in Hainan Southern China

作　　者：潘在兴[1] 潘健华[1] 夏欢[1] 叶芳丽[1] 杨瑶[1] PAN Zaixing;PAN Jianhua;XIA Huan;YE Fangli;YANG Yao(Clinical Laboratory of Haikou Municipal Hospital,Haikou,Hainan,China,570208)

机构地区：[1]海口市人民医院检验科,海南海口570208

出　　处：《分子诊断与治疗杂志》2022年第12期2027-2030,2035,共5页Journal of Molecular Diagnostics and Therapy

基　　金：海南省卫生健康委员会基金(21A200342)。

摘　　要：目的研究Livin、STAT3基因在海南地区甲状腺癌组织中的表达情况。方法纳入2020年10月至2021年12月期间海口市人民医院收治的48例甲状腺癌患者作为研究对象,所有患者均进行手术治疗,术中取患者甲状腺癌组织和癌旁组织标本(病灶边缘3 cm)进行研究。观察癌组织和癌旁组织中Livin、STAT3基因的表达情况,分析Livin和STAT3基因表达情况与甲状腺癌临床病理学的关系。结果甲状腺癌组织中Livin和STAT3基因的阳性表达率明显高于癌旁组织中Livin和STAT3基因,差异有统计学意义(x^(2)=51.064、51.242,P<0.05)。Livin、STAT3基因在甲状腺癌中的表达与患者临床分期、淋巴转移以及包膜浸润有关(x^(2)=3.117、4.493、3.760,P<0.05),与性别、年龄、肿瘤直径、病理类型等无关(x^(2)=0.048、0.112、0.519、0.013,P>0.05)。在甲状腺癌组织中Livin基因表达阳性的42例患者中有5例患者STAT3基因表达阴性,Livin基因表达阴性的6例患者中有3例患者STAT3基因表达阳性。两者在甲状腺癌组织中的表达呈正相关(r=0.412,P<0.05)。结论甲状腺癌组织中Livin和STAT3基因表达明显升高,两者的表达呈正相关,Livin和STAT3基因表达异常升高参与了甲状腺癌的发生和发展过程。Objective To study the expression of Livin and STAT3 genes in thyroid cancer tissues in Hainan region.Methods A total of 48 patients with thyroid cancer admitted to Haikou People’s Hospital between October 2020 and December 2021 were included as research subjects.All patients underwent surgical treatment,and thyroid cancer tissue and paracancerous tissue samples were taken during the operation(the lesion margin was 3cm)research.The expression of Livin and STAT3 genes in cancer tissues and adjacent tissues were observed,and the relationship between the expression of Livin and STAT3 genes and the clinicopathology of thyroid cancer was analyzed.Results The positive expression rates of Livin and STAT3 genes in thyroid cancer tissues were significantly higher than those in adjacent tissues,and the difference was statistically significant(x^(2)=51.064,51.242,P<0.05).The expression of Livin and STAT3 genes in thyroid cancer was associated with patient clinical stage,lymphatic metastasis,and capsule invasion(x^(2)=3.117、4.493、3.760,P<0.05),but not with sex,age,tumor diameter,and pathological type(x^(2)=0.048、0.112、0.519、0.013,P>0.05).Five out of 42 patients with positive Livin gene expression in thyroid cancer tissue were negative for STAT3 gene expression,and three out of six patients with negative Livin gene expression were positive for STAT3 gene expression.The expressions of the two in thyroid cancer tissues were positively correlated(r=0.412,P<0.05).Conclusion The expression of Livin and STAT3 genes in thyroid cancer tissue was significantly increased,and the expression of the two was positively correlated.The abnormal increase of Livin and STAT3 gene expression participated in the occurrence and development of thyroid cancer.

关 键 词：LIVIN STAT3 甲状腺癌 病理特征 基因表达 

分 类 号：R736.1[医药卫生—肿瘤]