TTF⁃1、CYFRA21⁃1在诊断非小细胞肺癌患者中的临床效果评价  

Evaluation of clinical effect of TTF⁃1 and CYFRA21⁃1 levels in the diagnosis of non⁃small cell lung cancer patients

作　　者：牛慧 程君[2] 刘芸芸 高炜[2] 刘武 田春香 NIU Hui;CHENG Jun;LIU Yunyun;GAO Wei;LIU Wu;TIAN Chunxiang(The Second Department of Radiotherapy,Qingdao Central Hospital,Affiliated Hospital of Qingdao University,Qingdao,Shandong,China,266000;Department of Traditional Chinese and Western Medicine,Qingdao Central Hospital,Affiliated Hospital of Qingdao University,Qingdao,Shandong,China,266000)

机构地区：[1]青岛大学附属医院青岛市中心医院放射治疗二科,山东青岛266000 [2]青岛大学附属医院青岛市中心医院中西医科,山东青岛266000

出　　处：《分子诊断与治疗杂志》2022年第12期2129-2132,共4页Journal of Molecular Diagnostics and Therapy

基　　金：青岛市中医药科研计划项目(2020⁃zyy030)。

摘　　要：目的分析甲状腺转录因子⁃1(TTF⁃1)、细胞角蛋白19片段抗原21⁃1(CYFRA21⁃1)水平在诊断非小细胞肺癌患者中的临床效果。方法选取2018年9月至2020年9月青岛大学附属医院青岛市中心医院收治的68例非小细胞肺癌患者作为研究组,另选取72名同时间段进行健康体检的健康人群作为对照组。比较68例非小细胞肺癌患者和72名健康人群、不同病理类型非小细胞肺癌患者(鳞癌、腺癌)、非小细胞肺癌不同分期(Ⅰ~Ⅱ期、Ⅲ~Ⅳ期)临床资料中TTF⁃1、CYFRA21⁃1水平差异,分析TTF⁃1、CYFRA21⁃1水平对非小细胞肺癌患者的诊断价值。结果研究组TTF⁃1、CYFRA21⁃1水平均高于对照组,差异有统计学意义(P<0.05)。TTF⁃1、CYFRA21⁃1联合检测诊断非小细胞肺癌的敏感度为0.823、特异度为0.941、AUC为0.938,明显高于单一TTF⁃1、CYFRA21⁃1的检测诊断结果(P<0.05)。不同病理类型非小细胞肺癌患者TTF⁃1、CYFRA21⁃1水平比较:腺癌<鳞癌,差异具有统计学意义(P<0.05)。Ⅲ~Ⅳ期非小细胞肺癌患者TTF⁃1、CYFRA21⁃1水平明显高于Ⅰ~Ⅱ期,差异有统计学意义(P<0.05)。结论相较于健康人群,非小细胞肺癌患者TTF⁃1、CYFRA21⁃1水平均异常升高;联合检测在非小细胞肺癌的早期诊断、TNM分期以及病理分型均具有较高的临床诊断应用效果,值得临床进一步研究。Objective To analyze of thyroid transcription factor⁃1(TTF⁃1)and cytokeratin 19 fragment antigen 21⁃1(Recombinant Cytokeratin Fragment Antigen 21⁃1,CYFRA21⁃1)levels in the diagnosis of non⁃small cell lung cancer patient effect.Methods 68 patients with non⁃small cell lung cancer admitted to our hospital from September 2018 to September 2020 were retrospectively selected as the research group,and 72 healthy people who underwent physical examination during the same period were selected as the control group.The levels of TTF⁃1 and CYFRA21⁃1 in the clinical data of 68 patients with non⁃small cell lung cancer,72 healthy people,patients with different pathological types of non⁃small cell lung cancer(squamous cell carcinoma,adenocarcinoma),and patients with different stages of non⁃small cell lung cancer(stagesⅠ~ⅡandⅢ~Ⅳ)were compared,and the diagnostic value of TTF⁃1 and CYFRA21⁃1 levels in patients with non⁃small cell lung cancer was analyzed.Results The levels of TTF⁃1 and CYFRA21⁃1 in the study group were higher than those in the control group(P<0.05).The sensitivity,specificity and AUC of TTF⁃1 and CyFRA21⁃1 combined in the diagnosis of non⁃small cell lung cancer were 0.823,0.941 and 0.938,respectively,which were significantly higher than those of TTF⁃1 and CyFRA21⁃1 alone detection,and the comparison was statistically significant(P<0.05).Comparison of TTF⁃1 and CYFRA21⁃1 levels in patients with different pathological types of non⁃small cell lung cancer:adenocarcinoma<squamous cell carcinoma,the difference was statistically significant(P<0.05).The levels of TTF⁃1 and CYFRA21⁃1 of non⁃small cell lung cancer patients in stageⅢtoⅣwere significantly higher than those in stageⅠtoⅡ(P<0.05).Conclusion The levels of TTF⁃1 and CYFRA21⁃1 in non⁃small cell lung cancer patients are abnormally higher than those in healthy people.Combined detection has high clinical diagnosis application effect,in the early diagnosis,TNM staging and pathological classific

关 键 词：TTF⁃1 CYFRA21⁃1 非小细胞肺癌 TNM分期 

分 类 号：R734.2[医药卫生—肿瘤]