脑小血管病认知障碍与外周血8-iso-PGF2α、P选择素水平的相关性分析  

Correlation between cognitive impairment in patients with cerebral small vessel disease and the levels of 8-isoprostaglandin F2αand P-selectin in peripheral blood

作　　者：王道合 施媛媛 安得英 杨勇 高生云 吴成斌 周伟 WANG Daohe;SHI Yuanyuan;AN Deying;YANG Yong;GAO Shengyun;WU Chengbin;ZHOU Wei(Department 2 of Neurology,Wuwei Tumor Hospital,Wuwei 733000,China;Department of Hepatology,Wiiwei TumorHospital,Wuwei 733000,China;Department of Cardiology,Wuwei Tumor Hospital,Wuwei 733000,China;Department of Medical Technology,Wuwei Tumor Hospital,Wuwei 733000,China)

机构地区：[1]甘肃省武威肿瘤医院神经内2科,甘肃武威733000 [2]甘肃省武威肿瘤医院肝病科,甘肃武威733000 [3]甘肃省武威肿瘤医院心血管专科,甘肃武威733000 [4]甘肃省武威肿瘤医院医技科室,甘肃武威733000

出　　处：《长春中医药大学学报》2023年第1期79-84,共6页Journal of Changchun University of Chinese Medicine

基　　金：武威市科技计划项目(WW2002054)。

摘　　要：目的探究脑小血管病(CSVD)认知障碍与外周血8-异前列腺素F2α(8-iso-PGF2α)、P选择素(PS)水平的相关性。方法选择脑小血管病患者82例,按照蒙特利尔认知评估量表(MoCA)评分分为研究组(合并认知障碍)与对照组(未合并认知障碍)。收集2组基线资料,测定外周血8-iso-PGF2α、PS水平,应用Pearson相关性分析探讨外周血8-iso-PGF2α、PS水平与脑小血管病患者MoCA评分关系,Logistic回归分析探讨脑小血管病患者认知障碍影响因素,并绘制受试者工作特征(ROC)曲线观察外周血8-iso-PGF2α、PS水平对脑小血管病患者认知障碍的预测效能。结果研究组高血压比例、总胆固醇(TC)水平较对照组高,MoCA评分较对照组低(P<0.05);研究组外周血8-iso-PGF2α、PS水平均较对照组高(P<0.05);Pearson相关性分析显示,外周血8-iso-PGF2α、PS水平与脑小血管病患者MoCA评分均呈显著负相关(P<0.05);Logistic回归分析显示,高血压与外周血8-iso-PGF2α、PS均为脑小血管病患者认知障碍影响因素(P<0.05);ROC曲线显示,8-iso-PGF2α、PS联合预测脑小血管病患者认知障碍的曲线下面积(AUC)为0.934,联合预测时灵敏度为77.27%、特异度为97.37%。结论脑小血管病认知障碍与外周血8-iso-PGF2α、PS水平密切相关,可作为预测脑小血管病患者出现认知障碍的候选指标。Objective To investigate the correlation between cognitive impairment in patients with cerebral small vessel disease(CSVD)and the levels of 8-isoprostaglandin F2α(8-iso-PGF2α)and P-selectin(PS)in peripheral blood.Methods A total of 82patients with CSVD in our hospital from June 2019 to June 2022 were selected and divided into a study group(with cognitive impairment)and a control group(without cognitive impairment)according to the Montreal Cognitive Assessment Scale(MoCA).The baseline data of the two groups were collected,and the levels of 8-iso-PGF2αand PS in peripheral blood were measured.Pearson correlation analysis was used to explore the relationship between peripheral blood 8-iso-PGF2αand PS levels and MoCA scores in CSVD patients,and Logistic regression analysis was used to explore the influencing factors for cognitive impairment in CSVD patients.Receiver operating characteristic(ROC)curves were drawn to observe the predictive effect of peripheral blood 8-iso-PGF2αand PS levels on cognitive impairment in CSVD patients.Results The proportion of hypertension and the level of total cholesterol(TC)in the study group were higher than those in the control group,while the MoCA score was lower than that in the control group(P<0.05).The levels of 8-iso-PGF2αand PS in peripheral blood of the study group were higher than those of the control group(P<0.05).Pearson correlation analysis showed that the levels of 8-iso-PGF2αand PS in peripheral blood were significantly negatively correlated with the MoCA scores in CSVD patients(P<0.05).Logistic regression analysis showed that hypertension,peripheral blood 8-iso-PGF2αand PS were the influencing factors for cognitive impairment in patients with CSVD(P<0.05).The ROC curve showed that the area under the curve(AUC)of cognitive impairment jointly predicted by 8-iso-PGF2αand PS in CSVD patients was 0.934,with a sensitivity of 77.27%and specificity of 97.37%.Conclusion Cognitive impairment in CSVD is closely related to the levels of 8-iso-PGF2αand PS in peripheral blood

关 键 词：脑小血管病 认知障碍 8-异前列腺素F2Α P选择素 

分 类 号：R743[医药卫生—神经病学与精神病学]