Prenatal and postnatal drug exposure:focus on persistent central effects  

作　　者：Giulia Costa Alexia E.Pollack 

机构地区：[1]Department of Biomedical Sciences,Section of Neuroscience,University of Cagliari,Cagliari,Italy [2]Department of Biology,University of Massachusetts-Boston,Boston,MA,USA

出　　处：《Neural Regeneration Research》2023年第8期1697-1702,共6页中国神经再生研究（英文版）

基　　金：supported by PON AIM(PON RICERCA E INNOVAZIONE 2014-2020,-AZIONE I.2.D.D.N.407 DEL 27 FEBBRAIO 2018-“ATTRACTION AND INTERNATIONAL MOBILITY”)(to GC);Fondazione CON IL SUD,The U.S.-Italy Fulbright Commission(to AEP)。

摘　　要：Clinical studies indicate significant use of prescription,nonprescription and social/recreational drugs by women during pregnancy;however,limited knowledge exists about the detrimental effects that this practice may have on the developing central nervous system of the fetus.Importantly,few experimental and clinical data are available on how gestational exposure could exacerbate the effects of the same or a different drug consumed by the offspring later in life.The present review summarizes recent findings on the central toxicity elicited by several classes of drugs,administered prenatally and postnatally in experimental animals and humans,focusing on prescription and nonprescription analgesics,anti-inflammatory agents,alcohol and nicotine.

关 键 词：3 4-methylenedioxymethamphetamine ACETAMINOPHEN alcohol CHLORPYRIFOS dexamethasone IBUPROFEN METHADONE neuroinflammation neurotoxicity nicotine 

分 类 号：R714[医药卫生—妇产科学]