Splenectomy does not affect mouse behaviors  

作　　者：Jiao-Qiong Guan Pei-Sen Zhang Wen-Chao Zhang Bing-Qian Zhang Hai-Tao Wu Yue Lan Ti-Fei Yuan 

机构地区：[1]Department of Rehabilitation Medicine,Guangzhou First People’s Hospital,School of Medicine,South China University of Technology,Guangzhou,Guangdong Province,China [2]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [3]College of Life Science and Technology,Beijing University of Chemical Technology,Beijing,China [4]Department of Neurobiology,Beijing Institute of Basic Medical Sciences,Beijing,China [5]Key Laboratory of Neuroregeneration,Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China [6]Guangzhou Key Laboratory of Aging Frailty&Neurorehabilitation,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》2023年第8期1789-1794,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.81772438,81974357;the Guangzhou Municipal Science and Technology Program,No.202206010197(all to YL)。

摘　　要：The spleen is critical for immunity.It is the largest immune organ and immune center in the peripheral system.While the relationship between behavior and immunity has been demonstrated in physiology and diseases,the role of the spleen in behavior is not clear.To investigate the effects of the spleen on behaviors,we performed a refined splenectomy procedure on C57BL/6J mice and performed an open field test,circadian rhythm test,elevated plus maze,sucrose preference test,and Barnes maze test.Splenectomy did not induce changes in general locomotion,circadian rhythms,learning and memory,or depression/anxiety-related behaviors.To further investigate the effects of spleen on stress susceptibility,we established mouse models of depression through chronic unpredictable mild stress.The behavioral performances of mice subjected to splenectomy showed no differences from control animals.These findings suggest that splenectomy does not cause changes in baseline behavioral performance in mice.

关 键 词：ANXIETY chronic unpredictable mild stress circadian rhythms DEPRESSION IMMUNITY learning locomotion memory SPLEEN SPLENECTOMY 

分 类 号：R657.6[医药卫生—外科学]