水通道蛋白4与卒中后认知障碍的关系研究进展  

Progress of the Relationship between Aquaporin 4 and Post-Stroke Cognitive Impairment

作　　者：梁潇 钱海兵 LIANG Xiao;QIAN Haibing(Guizhou University of Traditional Chinese Medicine,Guizhou Provincial Research Center for Consistency of Effectiveness of Authentic Medicinal Materials,Guiyang 550025,China)

机构地区：[1]贵州中医药大学,贵州省道地药材性效用一致性研究中心,贵阳550025

出　　处：《中国卒中杂志》2022年第12期1385-1390,共6页Chinese Journal of Stroke

基　　金：贵州省普通高等学校特色重点实验室项目(黔教合KY字[2017]006);贵州省优秀科技教育人才省长专项资金项目[黔省专合字(2012)167号]。

摘　　要：卒中后认知障碍是卒中的重要后遗症之一,从病理上可以分为血管性、退变性及混合性认知障碍。水通道蛋白4广泛分布于中枢神经系统,参与多种神经系统疾病和认知障碍的病理过程,但其参与卒中后认知障碍的具体机制目前尚未明确。本文综述水通道蛋白4通过参与调节神经炎症、突触可塑性以及β-淀粉样蛋白的积聚和清除过程在卒中后认知障碍中发挥的可能作用。Post-stroke cognitive impairment is one of the main sequelae of stroke,which can be divided into vascular,degenerative and mixed cognitive impairment.Aquaporin 4 is widely distributed in the central nervous system and is involved in the pathological process of cognitive impairment and multiple nervous system diseases.However,the specific mechanism of aquaporin 4 in post-stroke cognitive impairment is not clear.This article reviewed the possible important role of aquaporin 4 in post-stroke cognitive impairment by involvement in the regulation of neuroinflammation,synaptic plasticity,and the accumulation and clearance ofβ-amyloid.

关 键 词：水通道蛋白4 卒中后认知障碍 炎症因子 Β-淀粉样蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]