天然维生素E化合物研究进展  

Research Progress of Natural Vitamin E

作　　者：王月 王晶[1] 郭思瑞 徐文峰[1] 金鹏飞[1] 胡欣[1] WANG Yue;WANG Jing;GUO Sirui;XU Wenfeng;JIN Pengfei;HU Xin(Department of Pharmacy,Beijing Hospital·National Center of Gerontology·Institute of Geriatric Medicine,Chinese Academy of Medical Sciences·Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application,Beijing,China 100730)

机构地区：[1]北京医院药学部·国家老年医学中心·中国医学科学院老年医学研究院·北京市药物临床风险与个体化应用评价重点实验室<北京医院>,北京100730

出　　处：《中国药业》2023年第2期128-128,I0001-I0007,共8页China Pharmaceuticals

基　　金：国家自然科学基金[81803715]。

摘　　要：目的探讨不同天然型维生素E化合物之间药理活性的差异,为其研究和应用中维生素E亚型的选择提供依据。方法检索PubMed、Embase、中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方数据库中天然型维生素E化合物[包括生育酚(TF)和生育三烯酚(TT)]相关文献,总结其治疗潜力及药理学作用机制。结果与结论TT与TF因结构相似,均具有抗氧化和抗炎特性;又因结构差异,TT在治疗心血管系统、神经系统疾病及抗肿瘤等方面的疗效和健康收益更佳。目前,天然维生素E化合物的使用以α-TF为主,体内生物利用率低仍是TT应用的主要问题,探究TT高效提取和合成的方法是未来进一步实现其药用价值的前提和基础。Objective To investigate the differences in pharmacological activities among different natural vitamin E compounds,and to provide basis for the selection of vitamin E subtypes in the research and application.Methods Literature related to natural vitamin E compounds(including tocopherol and tocotrienol)in PubMed,Embase,CNKI,China Biology Medicine(CBM)and WanFang database were searched to summarize their therapeutic potential and pharmacological mechanism.Results and Conclusion Tocopherol and tocotrienol have similar structures,both of which have anti-oxidant and anti-inflammatory properties.Due to their structural differences,tocotrienol has better efficacy and health benefits in the treatment of cardiovascular system,nervous system diseases and anti-tumor.At present,the natural vitamin E compound mainly used isα-tocopherol,and low bioavailability in vivo is still the main problem in the use of tocopherol.Therefore,in-depth research on efficient extraction and synthesis methods of tocotrienol is the premise and basis for realizing its medicinal value in the future.

关 键 词：天然型维生素E 生育酚 生育三烯酚 异构体 药理活性 

分 类 号：R97[医药卫生—药品]