胸腺素β4表达与术前SII/ALB水平对早期可手术NSCLC患者预后的预测价值  

The prognostic value of thymosin β4 expression and preoperative systemic immune-inflammatory index/serum albumin level in early operable non-small cell lung cancer

作　　者：李红伟[1] 张保华[1] 郑瑶 周自强[1] Li Hongwei;Zhang Baohua;Zheng Yao;Zhou Ziqiang(Department of Pathology,Zibo Central Hospital,Zibo 255036,China)

机构地区：[1]淄博市中心医院病理科,淄博255036

出　　处：《中国医师杂志》2022年第12期1847-1851,1856,共6页Journal of Chinese Physician

摘　　要：目的探讨胸腺素β4(TMSB4X)表达与术前免疫炎症指数/血清白蛋白(SII/ALB)对早期可手术非小细胞肺癌(NSCLC)患者预后的预测价值。方法选取2016年1月至2021年1月淄博市中心医院收治的128例早期可手术NSCLC患者,均于术前检测TMSB4X、SII/ALB,按照TMSB4X表达分为TMSB4X阳性组(52例)与TMSB4X阴性组(76例),按SII/ALB值中位数分为高SII/ALB组(64例)、低SII/ALB组(64例),分析TMSB4X、SII/ALB与NSCLC患者临床特征的关系;以复发为终点事件,应用Kaplan-Meier法绘制生存曲线并用log-rank检验TMSB4X阳性组与阴性组、高SII/ALB组与低SII/ALB组无进展生存期(PFS)的差异,采用Cox单因素、多因素回归分析早期可手术NSCLC患者PFS的影响因素。结果TMSB4X阳性组与TMSB4X阴性组患者的病灶部位、癌胚抗原(CEA)、淋巴细胞计数(LY)比较差异有统计学意义(均P<0.05)。高SII/ALB组与低SII/ALB组患者的年龄、美国癌症联合会(AJCC)分期、ALB、CYFRA21-1、CEA、LY、PLT比较差异有统计学意义(均P<0.05)。TMSB4X阳性组中位PFS(17.11个月)低于TMSB4X阴性组(26.64个月)(log-rank P<0.001);高SII/ALB组中位PFS(15.82个月)低于低SII/ALB组(28.24个月)(log-rank P<0.001)。Cox单因素分析结果显示,病灶部位、AJCC分期、ALB、CYFRA21-1、CEA、LY、PLT、TMSB4X、SII/ALB均是早期可手术NSCLC患者PFS的影响因素(均P<0.05);多因素分析结果显示,AJCC分期、LY、TMSB4X、SII/ALB是早期可手术NSCLC患者PFS的独立影响因素(均P<0.05)。结论TMSB4X表达及术前SII/ALB水平可作为预测早期可手术NSCLC患者预后的指标。Objective To investigate the prognostic value of thymosinβ4(TMSB4X)expression and preoperative systemic immune-inflammatory index/serum albumin(SII/ALB)level in patients with early operable non-small cell lung cancer(NSCLC).Methods A total of 128 patients with early NSCLC admitted to Zibo Central Hospital from January 2016 to January 2021 were selected.TMSB4X and SII/ALB were detected before surgery,and they were divided into TMSB4X positive group(52 cases)and TMSB4X negative group(76 cases)according to TMSB4X expression.According to the median SII/ALB value,the patients were divided into high SII/ALB group(64 cases)and low SII/ALB group(64 cases).The relationship between TMSB4X,SII/ALB and clinical characteristics in patients with early operable NSCLC was analyzed.The survival curve was drawn by Kaplan-Meier method and the difference of progression free survival(PFS)between TMSB4X positive group and negative group,high SII/ALB group and low SII/ALB group was tested by log-rank.The influencing factors of PFS was analyzed by Cox univariate and multivariate regression.Results There were difference in lesion site,carcinoembryonic antigen(CEA)and lymphocyte count(LY)between TMSB4X positive group and TMSB4X negative group(all P<0.05).There were significant difference in age,American Joint Committee on Cancer(AJCC)stage,ALB,cytokeratin 19 fragment(CYFRA21-1),CEA,LY,platelet count(PLT)between the high SII/ALB group and the low SII/ALB group(all P<0.05).The median PFS of TMSB4X positive group(17.11 months)was lower than that of TMSB4X negative group(26.64 months)(log rank P<0.001);The median PFS(15.82 months)in the high SII/ALB group was lower than that in the low SII/ALB group(28.24 months)(log rank P<0.0001);Cox univariate analysis showed that lesion location,AJCC stage,ALB,CYFRA21-1,CEA,LY,PLT,TMSB4X,and SII/ALB were all factors influencing PFS in early operable NSCLC patients(all P<0.05);Multivariate analysis showed that AJCC stage,LY,TMSB4X,SII/ALB were independent factors influencing PFS in early operable NSCLC pa

关 键 词：癌 非小细胞肺 胸腺素Β4 血清白蛋白 免疫-炎症指数 

分 类 号：R734.2[医药卫生—肿瘤]