辛伐他汀联合银杏叶胶囊对急性脑梗死伴颈动脉粥样硬化患者的影响  

Effect of Simvastatin Combined with Ginkgo Biloba Capsule on Patients with Acute Cerebral Infarction and Carotid Atherosclerosis

作　　者：羊倩倩 沈德坤 Yang Qianqian;Shen Dekun(Department of Pharmacy,the Second Poples Hospital of Heze,Heze 274000)

机构地区：[1]山东省菏泽市第二人民医院药剂科,菏泽274000

出　　处：《国际老年医学杂志》2023年第1期41-44,共4页International Journal of Geriatrics

基　　金：山东省医药卫生科技发展科研项目(2018MD165)。

摘　　要：目的探究辛伐他汀联合银杏叶胶囊对颈动脉粥样硬化患者的斑块、氧化应激和炎症反应的影响。方法选择菏泽市第二人民医院2018年12月~2019年12月收治的急性脑梗死伴颈动脉粥样硬化斑块患者90例进行前瞻性研究,按照随机数字表法分成两组,各45例。两组均进行常规临床治疗,对照组给予辛伐他汀片,联合组在对照组基础上加服银杏叶胶囊,治疗6个月。比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、不稳定斑块占比以及氧化应激指标[血清中晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)、丙二醛(MDA)]和炎症反应指标[C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)]。结果治疗前,两组NIHSS评分、AOPP、SOD、MDA、CRP、TNF-α和IL-6比较,差异均无统计学意义(P>0.05);治疗后,联合组NIHSS评分及血清AOPP、MDA、CRP、TNF-α和IL-6低于对照组,SOD高于对照组,差异均有统计学意义(P<0.05)。结论辛伐他汀联合银杏叶胶囊可有效改善急性脑梗死伴颈动脉粥样硬化斑块患者的斑块稳定性以及氧化应激和炎症反应。Objective To study the effect of Simvastatin combined with Ginkgo bilobal capsule on plaque,oxidative stress and inflammatory response in patients with carotid atherosclerosis.Methods A prospective study was performed on 90 patients with acute cerebral infarction and carotid atherosclerotic plaque admitted to hospital from December 2018 to December 2019.The patients were divided into a control group and a combination group according to the random number table,45 patients in each group.Both groups received routine treatment and Simvastatin tablets for 6 months.The combination group additionally received Ginkgo biloba capsule.The following indices were compared between the two groups before and after treatment,including the score of National Institute of Health Stroke Scale(NIHSS),proportion of unstable plaque,the levels of oxidative stress indicators[serum advanced oxidation protein products(AOPP),superoxide dismutase(SOD),malondialdehyde(MDA)],and the levels of inflammatory response indicators[C-reactive protein(CRP),tumor necrosis factorα(TNF-α),and interleukin-6(IL-6)].Results Before treatment,there were no significant differences between the two groups in NIHSS score,AOPP,SOD,MDA,CRP,TNF-αand IL-6 levels(P>0.05).After treatment,NIHSS score,AOPP,MDA,CRP,TNF-αand IL-6 levels in the combination group were significantly lower than those in the control group,and SOD level was higher than that in the control group(P<0.05).Conclusion The combination of Simvastatin and Ginkgo biloba capsule may effectively improve plaque stability,oxidative stress and inflammatory response in patients with acute cerebral infarction and carotid atherosclerosis.

关 键 词：颈动脉粥样硬化 斑块稳定性 银杏叶胶囊 辛伐他汀 氧化应激 炎症反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]