βB2晶体蛋白晶体外功能研究进展  

Research progress of extracrystalline functions ofβB2-crystallin

作　　者：黄玮 李美慧 刘胜楠 顾仲毅 张俊洁 HUANG Wei;LI Mei-hui;LIU Sheng-nan;GU Zhong-yi;ZHANG Jun-jie(Department of Gynecology and Obstetrics,Changhai Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院妇产科,上海200433

出　　处：《中国临床医学》2022年第6期1030-1033,共4页Chinese Journal of Clinical Medicine

基　　金：长海医院“234学科攀登计划”临床创新项目(2019YXK027);海军军医大学第一附属医院青年启动基金(2020QNB07)。

摘　　要：B2晶体蛋白是脊椎动物晶状体中的主要结构蛋白,除在晶状体内发挥作用外,近年研究发现其在晶状体外也表现突出。βB2晶体蛋白高表达于视网膜、大脑、睾丸及卵巢,既可促进视神经轴突再生、保护损伤的视神经,还可影响感觉运动门控和海马功能,同时影响生殖功能,可能与胎儿流产相关。此外,最新研究还表明,βB2晶体蛋白与多种肿瘤的发生、发展相关。本文就βB2晶体蛋白的晶状体外功能及研究进展作一综述。B2-crystallin is the main structural protein in the vertebrate lens.In addition to lens,recent studies have found thatβB2-crystallin also plays a very prominent and even unique role outside the lens.βB2-crystallin is unexpectedly highly expressed in retina,brain,testis,and ovary.It can not only promote the regeneration of optic nerve axons,protect the injured optic nerve,but also affect sensory motor gating and hippocampal function,and even plays an important role in reproductive function,or even related to fetal abortion.In addition,new studies have shown thatβB2-crystallin is also related to the occurrence and development of a variety of tumors.This paper reviews the function and research progress ofβB2-crystallin function outside the lens.

关 键 词：B2晶体蛋白 视网膜 卵巢 流产 海马 肿瘤 

分 类 号：R363[医药卫生—病理学]