巨噬细胞极化调控颌骨再生的研究进展  

Research progress of macrophage polarization regulation of jaw regeneration

作　　者：刘琨 罗新 李君[2] 孟春秀[2] 张玉珏 吕兆勇[2] 刘凤珍[2] 张彬 LIU Kun;LUO Xin;LI Jun;MENG Chun-xiu;ZHANGYu-jue;LYU Zhao-yong;LIU Feng-zhen;ZHANG Bin(School and Hospital of Stomatology,Shandong University,Jinan,China;Liaocheng People􀆳s Hospital,Liaocheng 252000,China)

机构地区：[1]山东大学口腔医学院,山东省聊城市人民医院口腔科,聊城252000 [2]山东省聊城市人民医院生物材料实验室,聊城252000

出　　处：《口腔颌面修复学杂志》2023年第1期60-64,共5页Chinese Journal of Prosthodontics

基　　金：山东省自然科学基金(项目编号:ZR2021MH026);山东省自然科学基金(项目编号:ZR2022MH075);山东省医药卫生科技发展计划项目(项目编号:202108020440);聊城市重点研发计划政策引导类项目(项目编号:2022YDSF16)。

摘　　要：在人工骨生物材料植入颌骨后,免疫细胞特别是巨噬细胞在骨组织再生修复中发挥关键作用。植入初期,巨噬细胞呈现经典的M1促炎表型并聚集在缺损区域,M1型巨噬细胞能够诱导局部炎症反应,释放相关促炎因子;中后期巨噬细胞转化为M2型抗炎表型,M2型巨噬细胞能促进组织修复并加速伤口愈合。巨噬细胞M1和M2之间的平衡对炎症及骨组织愈合具有重要作用。骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)在骨修复过程中具有重要作用,巨噬细胞-BMSCs相互作用影响骨组织再生修复。本文综述巨噬细胞对BMSCs成骨分化在颌骨骨重建中的调控作用,为生物骨组织工程的临床应用提供新的思路。Immune cells,especially macrophages,play a key role in bone tissue regeneration and repair after artificial bone biomaterials are implanted into the jaw.Early macrophages accumulate in the defect area and first exhibit a classic M1-activated phenotype,inducing inflammatory response and releasing pro-inflammatory mediators.In the middle and late period,macrophages polarize to M2 type,accelerating the wound healing process and tissue repair.The balance between macrophages M1 and M2 is critical for inflammation and bone repair.Bone marrow mesenchymal stem cells(BMSCs)play an important role in bone tissue healing,and the interaction between macrophages and BMSCs is beneficial to bone tissue regeneration and repair.This paper reviews the regulation of macrophages on osteogenic differentiation of BMSCs in the process of mandibular bone reconstruction,providing new ideas for the clinical application of biological bone tissue engineering.

关 键 词：巨噬细胞极化 免疫调控 细胞间交互 成骨分化 

分 类 号：R780.2[医药卫生—口腔医学]