Diagnosis and management of intraocular lymphoma:a narrative review  

作　　者：Caroline C.Mussatto Akbar Shakoor 

机构地区：[1]University of Kansas School of Medicine,Kansas City,KS,USA [2]Department of Ophthalmology and Visual Sciences,John A.Moran Eye Center,University of Utah School of Medicine,Salt Lake City,UT,USA

出　　处：《Annals of Eye Science》2022年第3期55-66,共12页眼科学年鉴（英文）

摘　　要：Background and Objective:Intraocular lymphoma(IOL)is a heterogenous category of rare malignancies that are often misdiagnosed and underrecognized.The rarity of IOL impedes clinical research and contributes to difficulty in standardizing its management.In this article we review the existing scientific literature to identify the current diagnostic tools and discuss comprehensive management of various categories of IOL.Our objective is to increase disease recognition of IOL as a whole and explore updated management options for each subtype.Methods:PubMed and Embase were searched for publications using the terms‘intraocular lymphoma’,‘vitreoretinal lymphoma’,‘uveal lymphoma’,‘iris lymphoma’,‘choroidal lymphoma’and‘ciliary body lymphoma’published from 1990 to June 2021.Inclusion criteria were English language articles.Exclusion criteria were non-English language articles,case reports and animal studies.Key Content and Findings:IOL often presents in middle-aged and older patients with symptoms of floaters and vision changes,but a broad array of clinical signs and symptoms are possible depending upon subtype.IOL can be subdivided by location of involvement into vitreoretinal and uveal lymphoma.These subtypes express key differences in their pathophysiology,clinical presentation,histology,prognosis,and treatment.Primary vitreoretinal lymphomas(PVRL)generally originate from B-lymphocytes and are associated with central nervous system(CNS)lymphoma.Ophthalmic findings include retinal pigment epithelium changes with yellow subretinal deposits known as“leopard spotting.”Primary uveal lymphomas generally originate from low-grade B-lymphocytes invading the choroid and carry an improved prognosis compared to vitreoretinal lymphomas.Funduscopic findings of primary uveal lymphoma include yellow to pink-yellow choroidal swelling with infiltrative subconjunctival“salmon-patch”lesions.Diagnosis for IOL is often delayed due to insidious onset,low prevalence,and tendency to mimic diseases such as uveitis

关 键 词：Intraocular lymphoma(IOL) vitreoretinal lymphoma uveal lymphoma masquerade syndromes UVEITIS 

分 类 号：R739.7[医药卫生—肿瘤]