基于NMOF的纳米生物成像药物在外科实体肿瘤诊疗应用的研究进展  

Research progress of nanoscale metal-organic frameworks-based nanobioimaging drugs in the diagnosis and treatment of surgical solid tumors

作　　者：张涛[1] 李杰 朱坤[1] 时景伟[2] 马冲[1] 李晓燕[3] Zhang Tao;Li Jie;Zhu Kun;Shi Jingwei;Ma Chong;Li Xiaoyan(Department of Gastrointestinal Colorectal and Anal Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China;Department of Clinical Laboratory,China-Japan Union Hospital of Jilin University,Changchun 130033,China;Department of Infection Control,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学中日联谊医院胃肠结直肠肛门外科,长春130033 [2]吉林大学中日联谊医院检验科,长春130033 [3]吉林大学口腔医院医院感染管理部,长春130021

出　　处：《中华实验外科杂志》2022年第12期2510-2512,共3页Chinese Journal of Experimental Surgery

基　　金：吉林省教育厅"十三五"科学技术项目(JJKH20190204KJ、JJKH20211143KJ、JJKH20201027KJ)。

摘　　要：生物成像技术在外科实体肿瘤的诊疗过程中发挥重要作用。然而目前临床常用的小分子成像药物因自身药代动力学以及物理特性所导致的缺陷严重限制了其在外科实体肿瘤诊疗中的应用。纳米有机金属骨架(NMOF)作为一种理想的多功能纳米载体,其具有的优良特性如高表面积、可调节孔隙率、可控结构、尺寸和形态多样化、易于功能化和生物降解性,使其在生物成像领域具备应用潜能。现介绍NMOF在外科实体肿瘤领域作为成像试剂的研究进展。Bioimaging technology plays an important role in the diagnosis and treatment of surgical solid tumors.However,the defects of the currently commonly used small-molecule imaging drugs due to their own pharmacokinetics and physical properties seriously limit their application in the diagnosis and treatment of surgical solid tumors.As an ideal multifunctional nanocarrier,nanoscale metal-organic frameworks(NMOFs)possess excellent properties such as high surface area,tunable porosity,controllable structure,diversification of size and morphology,and easy functionalization.It has application potential in the field of bioimaging because of its chemical and biodegradability.We will introduce the research progress of NMOFs as imaging agents in the field of surgical solid tumors from the following areas.

关 键 词：纳米生物成像 纳米有机金属骨架 实体肿瘤 外科 

分 类 号：R730.5[医药卫生—肿瘤]