SOCS-3在肝脏疾病中的作用研究进展  

Research progress on the role of SOCS-3 in liver diseases

作　　者：晏远智[1] 杨哲[2] 胡曦丹 马开利 唐恒[1] 游晶[4] Yan Yuanzhi;Yang Zhe;Hu Xidan;Ma Kaili;Tang Heng;You Jing(Department of Pharmacy,The First Affiliated Hospital of Kunming Medical University;Department of Pathology,The First Affiliated Hospital of Kunming Medical University;Center for Drug Safety Evaluation and Research Institute of Medical Biology,Chinese Academy of Medical Sciences;Department of Infectious Diseases and Liver Diseases,The First Affiliated Hospital of Kunming Medical University)

机构地区：[1]昆明医科大学第一附属医院药剂科,昆明650031 [2]昆明医科大学第一附属医院病理科,昆明650031 [3]中国医学科学院医学生物学研究所药物安全性评价研究中心,昆明650000 [4]昆明医科大学第一附属医院感染性疾病和肝病科,昆明650031

出　　处：《重庆医科大学学报》2022年第10期1154-1158,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81760111、81760617);云南省教育厅科研基金资助项目(编号:2020J0157)。

摘　　要：细胞因子信号转导抑制蛋白-3(suppressor of cytokine signaling,SOCS-3)是一种细胞因子信号转导阻抑蛋白,参与体内多种信号转导通路的调节。研究发现,SOCS-3与肝纤维化、病毒性肝炎和肝肿瘤的发生发展均存在一定的关系,并且干扰素的抗病毒疗效与SOCS-3的遗传学表达改变密切相关。本综述将对SOCS-3的结构、分子功能及近年来在肝疾病中的相关研究进行简要总结。Suppressor of cytokine signaling-3(SOCS-3)is a kind of cytokine signaling transduction inhibitory protein,involving in the regulation of multiple signal transduction pathways in vivo. It’s found that SOCS-3 plays an important role in the occurrence and development of liver fibrosis,viral hepatitis and liver tumors,and the antiviral efficacy of interferon is closely related to the genetic expression of SOCS-3. This review briefly summarizes the structure and molecular function of SOCS-3 and related research in liver diseases in recent years.

关 键 词：SOCS-3 JAK/STAT信号通路 病毒性肝炎 肝纤维化 肝细胞癌 肝脏疾病 

分 类 号：R575[医药卫生—消化系统] R361.3[医药卫生—内科学]