免疫治疗时代下肺结核对肺癌发生、发展及治疗策略的影响  

Effect of pulmonary tuberculosis on occurrence, development and treatment strategies of lung cancer in immunotherapy era

作　　者：李燕 倪婷婷(综述)[2] 唐菲 张瑜(审校)[2,3] LI Yan;NI Tingting;TANG Fei;ZHANG Yu(First Clinical College,Zunyi Medical University,Zunyi,Guizhou 563000,China;Department of Oncology,Guizhou Provincial People’s Hospital,Guiyang,Guizhou 550002,China;National Health Commission Key Laboratory of Diagnosis and Treatemnt of Pulmonary Immune-Related Diseases,Guiyang,Guizhou 550002,China)

机构地区：[1]遵义医科大学第一临床学院,贵州遵义563000 [2]贵州省人民医院肿瘤科,贵阳550002 [3]国家卫生健康委肺脏免疫性疾病诊治重点实验室,贵阳550002

出　　处：《重庆医学》2023年第2期288-293,共6页Chongqing medicine

基　　金：贵州省高层次新型人才基金项目(GZSYQCC[2016]003);贵州省卫生健康委科学技术基金项目(gzwjkj2020-1-032,gzwkj2022-028);连云港市蕙兰公益基金(HL-HS2020-33);贵州省人民医院青年基金项目(GZSYQN[2021]03);科创-齐鲁肿瘤疾病研究基金项目(KC2021-JX-0186-131)。

摘　　要：中国是结核病高负担国家,结核病患病人数居全球第2位,肺癌是全球死亡率最高的癌症,也是中国癌症致死的首位原因。肺结核患者的肺癌发病率明显增加,而合并肺结核的肺癌患者的死亡率也有所上升,在高发病率及高死亡率的疾病负担下,肺结核与肺癌发生发展的机制是亟待解决的重点与难点。近年来,免疫治疗的应用使得肺癌的治疗取得了巨大进步,而免疫微环境的改变可能是肺结核和肺癌之间相互作用的重要联系,因此,该文将从肺结核与肺癌的相互作用关系及合并肺结核的肺癌患者治疗策略的研究进展方面探讨免疫治疗时代下肺结核对肺癌发生、发展及治疗策略的影响。China is a country with a high burden of tuberculosis, and the number of tuberculosis patients ranks the second in the world.Lung cancer is the cancer with the highest mortality rate in the world and the leading cause of cancer-related death in China.The incidence of lung cancer in the patients with tuberculosis has been significantly increased, while the mortality rate of lung cancer patients with complicating tuberculosis is also increased, under the disease burden of high morbidity and high mortality, the mechanism of the occurrence and development of pulmonary tuberculosis and lung cancer is the key and difficult point to be solved urgently.In recent years, the treatment of lung cancer has made great progress due to the application of immunotherapy, while changes in the immune microenvironment may be an important link in the interaction between tuberculosis and lung cancer.Therefore, this review intends to explore the impact of pulmonary tuberculosis on the occurrence, development and treatment strategies of lung cancer in the era of immunotherapy, from the perspective of the interaction between tuberculosis and lung cancer and the research progress of treatment strategies for lung cancer patients with tuberculosis.

关 键 词：肺癌 肺结核 免疫微环境 免疫治疗 综合治疗 

分 类 号：R734.2[医药卫生—肿瘤]