肠道微生物群-肠-脑轴在神经精神系统疾病中的研究进展  

Research progress of gut microbiota-gut-brain axis in neuropsychiatric disorders

作　　者：崔佳瞿 陈启仪 李宁[1,2] CUI Jiaqu;CHEN Qiyi;LI Ning(Intestinal Microenvironment Treatment Center(Department of Colorectal Disease),Shanghai Tenth People’s Hospital;Clinical Research Center for Digestive Diseases,Tongji University,Shanghai 200072,China)

机构地区：[1]同济大学附属上海市第十人民医院肠道微生态诊疗中心(结直肠病专科) [2]同济大学消化系统疾病临床研究中心,上海200072

出　　处：《上海医药》2023年第1期14-18,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金面上项目(81670493);上海申康医院发展中心临床三年行动计划项目(SHDC2020CR4026);上海市科学技术委员会医学创新行动计划项目(21Y11908300)。

摘　　要：肠-脑轴在维持机体内平衡方面起着重要作用,而肠道微生物群在肠道和大脑的双向沟通中扮演着重要角色,故学者们建立了肠道微生物群-肠-脑轴这一概念。肠道微生物群可通过神经、免疫、神经内分泌和代谢途径对宿主产生影响,包括神经发育、传递和行为,并参与多种神经精神系统疾病的发生发展。本文根据目前国内外的研究进展,结合本中心的临床经验,对肠道微生物群、肠道、神经系统之间的相互作用关系,肠道微生物群-肠-脑轴在神经精神系统疾病发生发展中扮演的角色,以及以肠道微生物群为神经精神系统疾病治疗靶点的肠-脑轴干预策略进行讨论,以期为神经精神系统疾病治疗提供一些新的理念和方法。The gut-brain axis and gut microbiota play an important role in maintaining homeostasis and the bidirectional communication between the gut and the brain,respectively.Therefore,scholars established the concept of a gut microbiota-gut-brain axis.Gut microbiota may affect the host through neural,immune,neuroendocrine,and metabolic pathways,including nerve development,transmission and behavior,and participates in the occurrence and development of a variety of neuropsychiatric diseases.In this review,we discussed the interaction among gut microbiota,gut and brain,the role of gut microbiota-gut-brain axis in the occurrence and development of neuropsychiatric diseases including depression,anxiety,autism spectrum disorders,Alzheimer’s disease,Parkinson’s disease and irritable bowel syndrome,and the intervention strategy of gut-brain axis with gut microbiota as therapeutic target for neuropsychiatric diseases based on the current research progress at home and abroad and the clinical experience of the center,so as to provide some new ideas and methods for the treatment of neuropsychiatric diseases.

关 键 词：肠道微生物群 肠-脑轴 神经精神系统疾病 

分 类 号：R363.21[医药卫生—病理学] R454.9[医药卫生—基础医学]