儿童原发性阿米巴脑膜脑炎1例并文献复习  

Primary amoebic meningoencephalitis in children: a case report and literature review

作　　者：韩玫瑰[1] 王志远 李树军[1] 韩子明[1] 黄倩[1] 朱小娟 张芳敏[1] Han Meigui;Wang Zhiyuan;Li Shujun;Han Ziming;Huang Qian;Zhu Xiaojuan;Zhang Fangmin(Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China)

机构地区：[1]新乡医学院第一附属医院儿科,卫辉453100

出　　处：《中华实用儿科临床杂志》2022年第19期1501-1503,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210505)。

摘　　要：报道新乡医学院第一附属医院2022年3月6日收治的1例儿童原发性阿米巴脑膜脑炎(PAM)。先证者, 男, 14岁, 因"发热、头痛、呕吐2 d"入院。脑脊液病原宏基因二代测序提示福氏耐格里阿米巴感染, 确诊为PAM。患儿病情进展迅速, 入院29 h死亡。文献检索共收集儿童PAM相关文献13篇, 共报道15例, 其中存活1例, 死亡14例。本病发病率低, 病情凶险, 死亡率高, 多数病例通过尸检或脑脊液查找病原体诊断, 本例患儿通过病原宏基因二代测序确诊, 为国内外报道较少的病例。A case of primary amoebic meningoencephalitis(PAM)treated in the First Affiliated Hospital of Xinxiang Medical University in March 6,2022 was reported.The proband was a 14-year-old boy,who was admitted to the hospital because of"fever,headache and vomiting for 2 days".Metagenomic next-generation sequencing(mNGS)was consequently conducted to examine the pathogens in cerebrospinal fluid.Naegleria infection was detected,so the child was diagnosed with PAM.The disease developed rapidly,and the patient died 29 hours after admission.In the paper,a total of 13 studies were reviewed,and 15 children with PAM were reported.Of the reported cases,only 1 case survived,14 cases died.PAM had a low incidence,a dangerous condition,and high mortality.Most cases were diagnosed by autopsy or pathogen diagnosis in cerebrospinal fluid.This case is confirmed by mNGS of pathogens,and it is rarely reported at home and abroad.

关 键 词：原发性阿米巴脑膜脑炎 福氏耐格里阿米巴 文献复习 儿童 

分 类 号：R742.9[医药卫生—神经病学与精神病学]