听神经瘤的非手术治疗研究进展  

Research progress on non-surgical treatment of vestibular schwannomas

作　　者：徐茂翔 姜雨萌 姚青秀 于栋祯[1] XU Maoxiang;JIANG Yumeng;YAO Qingxiu;YU Dongzhen(Department of Otorhinolaryngology Head and Neck Surgery,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai,200233,China)

机构地区：[1]上海市第六人民医院耳鼻咽喉头颈外科,上海200233

出　　处：《临床耳鼻咽喉头颈外科杂志》2022年第12期971-976,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目前听神经瘤的治疗方式以手术治疗为主,考虑到手术带来的多种并发症风险和患者的主/客观条件,非手术治疗中的立体定位放射治疗逐渐成为听神经瘤治疗的一部分。研究表明,伽马刀治疗对较小的肿瘤治疗效果较突出,并可缓解因肿瘤占位带来的面神经及听神经疾病。赛博刀不仅对肿瘤的控制效果较好,而且患者的听功能保留率也较为理想。质子束疗法也逐渐应用于听神经瘤的治疗,但还需进一步研究。药物治疗(包括多种靶点抑制剂与抗血管生成药物)目前多聚焦于临床前研究。本文对多种放射治疗临床研究与药物治疗进展进行综述。At present, the main treatment for vestibular schwannomas is surgery. Considering the risk of multiple complications from surgery and the subjective and objective conditions of patients, a non-surgical treatment modality, namely stereotactic radiotherapy, has gradually been included in the treatment of vestibular schwannomas. Studies have shown that Gamma Knife therapy has a more prominent therapeutic effect on smaller tumors and can alleviate facial nerve disorders caused by space occupying of tumor mass. Cyberknife not only has a better effect on tumor control, but also has an ideal retention rate for patients’ auditory function. Proton beam therapy has also been gradually applied to the treatment of vestibular schwannomas, but the effect of treatment remains to be further studied. Drug therapy includes a variety of target inhibitors and anti-angiogenic drugs. At present, drug treatment focuses more on preclinical research. This article reviews the clinical research of various radiotherapy and the progress of drug treatment.

关 键 词：听神经瘤 放射治疗 药物治疗 听功能 

分 类 号：R739.43[医药卫生—肿瘤]