宫颈癌患者血清Th1/Th2相关细胞因子表达与病理特征及预后关系  

the correlation of the expression levels of Th1/Th2 related cytokines of women with cervical cancer and their pathological characteristics and prognosis

作　　者：马金枝 李巧莉 朱夕雅 祝莉[1] MA Jinzhi;LI Qiaoli;ZHU Xiya;ZHU Li(Sanmenxia Hospital of Yellow River,Sanmenxia,Henan Province,472000;Sanmenxia Central Hospital)

机构地区：[1]黄河三门峡医院,472000 [2]河南省三门峡市中心医院

出　　处：《中国计划生育学杂志》2023年第1期214-217,共4页Chinese Journal of Family Planning

基　　金：三门峡市科技发展计划项目(2021004008)。

摘　　要：目的:探讨宫颈癌患者血清中Th1/Th2相关细胞因子表达与病理特征及预后关系。方法:回顾性收集2020年1月-2021年1月在本院接受治疗的宫颈癌患者82例临床资料(宫颈癌组),同期体检健康女性68例作为对照组,收集两组晨空腹静脉血检测血清Th1/Th2相关细胞因子水平;对比不同分化程度、不同临床分期、不同预后结局宫颈癌患者Th1/Th2相关细胞因子水平,采用Spearman相关系数分析Th1/Th2相关细胞因子与宫颈癌患者预后的关系。结果:血清干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、IL-4、IL-6水平,宫颈癌组(33.24±7.25、24.17±6.22、25.38±5.92、30.83±8.02)pg/ml与对照组均存在差异(51.29±8.76、37.45±8.03、13.32±3.41、20.82±5.47)pg/ml(均P<0.05);宫颈癌组随着分化程度及临床分期的升高上述指标上述指标异常加剧;对宫颈癌组随访1年,病死组(17例)各指标水平均高于存活组,IFN-γ、IL-2、IL-4、IL-6水平与宫颈癌患者不良预后均呈正相关(均P<0.05)。结论:宫颈癌患者血清Th1/Th2相关细胞因子水平表达异常,且与不良预后结局正相关。临床可通过监测宫颈癌患者Th1/Th2相关细胞因子水平及早开展诊疗方案,以改善患者预后。Objective:To investigate the correlation of the expression levels of Th1/Th2 related cytokines of women with cervical cancer and their pathological characteristics and prognosis.Methods:The clinical data of 82 patients with cervical cancer(in study group)who had treated in hospital from January 2020 to January 2021 were collected.68 healthy women who had received physical examination in hospital were selected in control group during the same period.The morning fasting elbow venous blood of the women in the two groups was collected for detect the levels of their Th1/Th2 related cytokines.The levels of the Th1/Th2 related cytokines were compared among of the women with different differentiation degrees,among of the women with different clinical stages,and among of the women with different prognostic outcomes in the study group.The correlation between the levels of Th1/Th2 related cytokines of the women with cervical cancer and their prognosis was analyzed by Spearman correlation coefficient analysis.Results:The levels of serum interferon-γ(IFN-γ,33.24±7.25),interleukin(IL)-2(24.17±6.22),IL-4(25.38±5.92),and IL-6(30.83±8.02pg/ml)of the women in the study group had significantly different from those(51.29±8.76 pg/ml,37.45±8.03 pg/ml,13.32±3.41 pg/ml,and 20.82±5.47 pg/ml)of the women in the control group(all P<0.05).With the increase of differentiation degree and clinical stage of cervical cancer of the women in the study group,the abnormal levels of serum IFN-γ,IL-2,IL-4,and IL-6 of the women had aggravated.In the study group,the levels of serum IFN-γ,IL-2,IL-4,and IL-6of the women with death were significantly higher than those of the survival womeduring 1-year of follow-up,and which were positively correlated with the poor prognosis of these women(all P<0.05).Conclusion:The level of serum Th1/Th2related cytokines of the women with cervical cancer is abnormal,and which is positively correlated with the poor prognosis of these women.In order to improve the prognosis of the women with cervical cancer,early

关 键 词：宫颈癌 TH1/TH2细胞因子 病理特征 预后 相关性 

分 类 号：R737.33[医药卫生—肿瘤]