喀什地区胃食管反流病流行病学调查及其危险因素分析  

Epidemiological investigation and risk factors of gastroesophageal reflux disease in Kashgar area

作　　者：卡哈尔·吐尔逊 阿地力江·阿力甫 艾山江·阿帕尔 买买提吐尔逊·吐尔迪[1] 唐荣华 吴源泉[1] 徐褀林 克力木·阿不都热依木[3] Kahar·Tuerxun;Ardijiang·Tuerxun;Ai Shanjiang·Tuerdi;Maimaitituerxun·Tuerdi;TANG Rong-hua;WU Yuan-quan;XU Qi-lin;Kelimu·Adudu Reyimu(Department of General Surgery,the First People's Hospital of Kashgar,84000 Kashgar,Xinjiang,China;Department of Pharmacy,the First People's Hospital of Kashgar,844000 Kashgar,China;Department of Minimally Invasive,Hernia and Abdominal Surgery,Xinjiang Uygur Autonomous Region People's Hospital,83000 Urumqi,China)

机构地区：[1]喀什地区第一人民医院普外二科,新疆喀什844000 [2]喀什地区第一人民医院药学部,新疆喀什844000 [3]新疆维吾尔自治区人民医院微创、疝和腹部外科,新疆量乌鲁木齐830000

出　　处：《临床消化病杂志》2022年第6期409-415,共7页Chinese Journal of Clinical Gastroenterology

基　　金：新疆维吾尔自治区天山青年计划-基层青年科技人才培养项目(2018Q142);喀什地区第一人民医院朝阳人才培养项目。

摘　　要：[目的]探讨新疆喀什地区胃食管反流病(GERD)患病情况、分布特征、及其分析危险因素。[方法]2020-03-2020-10期间采用整群抽样和分层抽样的方法对喀什地区18~80岁5080例常住居民进行问卷调查,内容包括基本信息、临床特点、生活习惯、饮食习惯、GERD-Q评分表等。[结果]5080例中患GERD 1187例(暴露组),GERD患病率为23.4%,1周之内发生1 d、2~3 d及4~7 d因反流症状致生活质量受到影响的人群分别为12.5%、6.4%及4.4%,15.4%;未患GERD者3873例(非暴露组)。暴露组超重或肥胖、饮酒、饱食、便秘以及口服降压药、他汀类药物、非甾体类抗炎药等各类慢性病药的人群分布高于非暴露组(P<0.05)。暴露组经常食用甜食、腌制品、烤制品、辛辣食物、咖啡、酸性饮料、冷饮、肉类、动物内脏的人群明显高于非暴露组,而经常食用鱼类、奶类、蛋类、蔬菜、水果等食物的人群明显低于非暴露组,2组比较均差异有统计学意义(P<0.05)。对居民特征进行Logistic回归分析后发现维吾尔族(对于汉族)、30~39岁年龄段、饮酒、经常饱食、便秘、经常服药是GERD危险因素(P<0.05,OR>1),对不同饮食习惯的患者进行多因素Logistic回归分析发现甜食、烤制品、冷饮、辛辣食物是GERD的独立危险因素(P<0.05,OR>1)。蛋类、蔬菜是保护因素(P<0.05,OR<1)。[结论]在新疆喀什地区本病发病率高于其他地区、具有一定的分布特征。原因与其地理环境、长期生活在本地区人群的特殊生活、饮食习惯有关。[Objective]To explore the possible risk factors of gastroesophageal reflux disease(GERD)by investigating its distribution in Kashgar area.[Methods]From march 2020 to october 2020,cluster and step sampling were used to conduct a questionnaire survey among 5080 permanent residents aged 18-80 in Kashi area,including basic information,clinical features,reflux diseases,living customs,eating habits and GERD-Q score.[Results]The total prevalence was 23.4%(1187/5080).The prevalence of reflux symptom within 1 day,2-3 days and 4-7 days in a week were 12.5%,6.4%and 4.4%respectively,and life quality of 15.4%of the population affected by reflux symptoms.The prevalence of GERD in people who were overweight or obese,alcohol drinking,satiation,constipate,and take medication were higher than the non exposure group.The prevalence of GERD in the people who always eat sweets,pickled products,roasted products,spicy food,coffee,acidic beverages,cold drinks,meat and fish were significantly higher than that in the non exposure group,and the difference was statistically significant(P<0.05).The prevalence of GERD in people who regularly eat fish,milk,eggs,vegetables,fruits were significantly lower than that in the non exposure group,and the difference was statistically significant(P<0.05).Logistic regression on the characteristics of the residents of the survey subjects found that uyghur nationality(to the han nationality),age(to the 30-39 age group),drinking,frequent satiation,constipation,and frequent medication were risk factors(P<0.05,OR>1).Multivariate Logistic regression analysis showed that sweets,baked products,cold drinks,and spicy foods were independent risk factors(P<0.05,OR>1).Eggs and vegetables were protective factors(P<0.05,OR<1).[Conclusion]The incidence of GERD is higher than that in other regions in Kashgar,and it has spatial distribution characteristics.The reasons may be related to the living environment,life styles and eating habits of this region.

关 键 词：胃食管反流 喀什地区 流行病学研究 危险因素 

分 类 号：R573.9[医药卫生—消化系统]