血清sCD40L、YKL-40、Aβ1-42水平与急性脑梗死患者认知障碍的相关性  

Correlation of serum levels of sCD40L,YKL-40and Aβ1-42 with cognitive impairment in patients with acutecerebral infarction

作　　者：杨帆 丁桂兵[2] 刘梅[2] 吴晋[2] 陈亮[2] YANG Fan;DING Guibing;LIU Mei(Nanjing Universityof Science and Technology Hospital,Nanjing210o94,CHINA)

机构地区：[1]南京理工大学医院,江苏210094 [2]南京医科大学第二附属医院神经内科

出　　处：《江苏医药》2022年第12期1217-1220,共4页Jiangsu Medical Journal

基　　金：江苏省自然科学基金(BK20191500)。

摘　　要：目的 分析血清可溶性白细胞分化抗原40配体(sCD40L)、软骨糖蛋白39(YKL-40)和β淀粉样蛋白1-42(Aβ1-42)水平与急性脑梗死(ACI)患者卒中后认知障碍(PSCI)的相关性。方法 112例ACI患者依据发病后3个月蒙特利尔认知评估量表(MoCA)评分结果分为认知障碍组(CI组,MoCA评分<26分,59例)和认知正常组(CN组,MoCA评分≥26分,53例),同时对60例健康成年人行MoCA评分作为对照(对照组)。比较三组血清sCD40L、YKL-40和Aβ1-42水平,分析其与MoCA评分的相关性。结果 CI组MoCA命名、视空间与执行功能、注意力、定向力、语言、抽象思维和记忆得分均低于CN组(P<0.05)。三组血清sCD40L和YKL-40水平依次为CI组>CN组>对照组,血清Aβ1-42水平依次为对照组>CN组>CI组(P<0.05)。ACI患者血清sCD40L和YKL-40水平与MoCA评分呈负相关(r_(s)=-0.63和-0.84,P<0.05),血清Aβ1-42水平与MoCA评分呈正相关(r_(s)=0.75,P<0.05)。血清sCD40L、YKL-40和Aβ1-42水平诊断PSCI的ROC曲线下面积分别为0.669、0.772和0.722。结论 ACI患者血清sCD40L、YKL-40和Aβ1-42水平与认知功能相关,有助于诊断PSCI。Objective To analyze the correlation of serum levels of soluble cluster of differentiation antigen 40 ligand(sCD40L),chitinase-3-like protein 1(YKL-40),and β-amyloid 1-42(Aβ1-42) with post-stroke cognitive impairment(PSCI) in the patients with acute cerebral infarction(ACI).Methods According to MoCA score in 3 months after stroke, 112 patients with ACI were divided into two groups of CI(with cognitive impairment, MoCA score<26 points, 59 cases) and CN(with normal cognition, MoCA score≥26 points, 53 cases). Another 60 healthy people were taken as the controls(group C). Serum levels of sCD40L, YKL-40 and Aβ1-42 were compared among the three groups, and the correlation between them and MoCA score was analyzed.Results The scores of naming, visual space and executive function, attention, orientation, language, abstract thinking and memory in group CI were lower than those in group CN(P<0.05).Serum levels of sCD40L and YKL-40 were in an order of group CI>group CN>group C, which of Aβ1-42 was in an order of group C>group CN>group CI(P<0.05).Serum levels of sCD40L and YKL-40 were negatively correlated with MoCA score(r_(s)=-0.63 and-0.84,P<0.05),and serum level of Aβ1-42 was positively correlated with MoCA score in the patients with ACI(r_(s)=0.75,P<0.05).The areas under ROC curve for serum levels of sCD40L,YKL-40 and Aβ1-42 to diagnose PSCI were 0.669,0.772 and 0.722,respectively.Conclusion Serum levels of sCD40L, YKL-40 and Aβ1-42 in the patients with ACI are closely related to cognitive function, which are helpful for the diagnosis of PSCI.

关 键 词：可溶性白细胞分化抗原40配体 软骨糖蛋白39 β淀粉样蛋白1-42 急性脑梗死 认知障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]