OCT和OCTA生物学标志物在糖尿病性黄斑水肿中应用的研究进展  

Research progress on the application of optical coherence tomography and angiography biomarkers in diabetic macular edema

作　　者：薛媛媛 陈晓隆[1] XUE Yuanyuan;CHEN Xiaolong(Department of Ophthalmology,Shengjing Hospital of China Medical University,Shenyang 110001,Liaoning Province,China)

机构地区：[1]中国医科大学附属盛京医院眼科,辽宁省沈阳市110001

出　　处：《眼科新进展》2023年第1期76-81,共6页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81570866)。

摘　　要：糖尿病性黄斑水肿(DME)是导致糖尿病患者视力丧失的重要原因。光学相干断层扫描(OCT)检查能够清晰地显示黄斑区视网膜和脉络膜的细微结构,并对黄斑区各组织层次结构进行定性和定量分析。OCT血管成像(OCTA)是在OCT基础上发展而来的一种非侵入性血管成像技术,具有无创、高速、高分辨率的特点,可提供视网膜和脉络膜血管结构的三维图像,实现病变的定量检测和分层检测。通过OCT观察黄斑区视网膜的形态和细微结构及OCTA评估血流变化已成为DME的研究热点。本文就OCT和OCTA各生物学标志物在DME病程发展及其抗血管内皮生长因子药物治疗中的应用进行阐述,以期为评估DME的严重程度、调整治疗方案并判断疾病预后提供参考。Diabetic macular edema(DME)is the leading cause of visual loss in patients with diabetes mellitus.Optical coherence tomography(OCT)can reflect fine structures of the retina and choroid in the macular region and realize the qualitative and quantitative analysis of the tissues.Optical coherence tomography angiography(OCTA),a non-invasive technology developed based on OCT,can provide three-dimensional images of the vascular structure of the retina and choroid,achieving quantitative and stratified detection of lesions.It shows high efficiency and high resolution.The observation of macular retina morphology and microstructure by OCT and the evaluation of blood velocity change by OCTA have become research hotspots of DME.In this paper,the roles of OCT and OCTA biomarkers in DME progression and their application in anti-vascular endothelial growth factor drug therapy were described to provide a reference for evaluating the severity of DME,adjusting the therapeutic schedule and judging the prognosis.

关 键 词：光学相干断层扫描 光学相干断层扫描血管成像 糖尿病性黄斑水肿 血管内皮生长因子 

分 类 号：R774[医药卫生—眼科]