肝细胞癌组织中PHF2表达与临床病理特征及预后的关系  

Relationship of plant homeodomain finger protein 2 expression with clinicopathological features and prognosis in hepatocellular carcinoma

作　　者：杨军[1] 孙龙[2] 赵健全 季骊 宋辉[2] YANG Jun;SUN Long;ZHAO Jianquan(Department of General Surgery,Qidong Peoples Hospital,Jiangsu,Qidong 226200,China)

机构地区：[1]江苏省启东市人民医院普通外科,226200 [2]江苏省启东市人民医院病理科,226200 [3]江苏省启东市人民医院检验科,226200

出　　处：《临床外科杂志》2022年第11期1041-1043,共3页Journal of Clinical Surgery

摘　　要：目的探讨肝细胞癌病人癌组织中PHF2表达与临床病理特征及预后的关系。方法2015年1月~2019年1月收治的肝细胞癌病人121例,收集其癌组织及对应的癌旁组织标本,检测组织中PHF2表达,随访病人3年,分析肝细胞癌组织中PHF2表达情况及与临床病理参数和预后的关系。多因素Cox回归分析肝细胞癌预后相关的危险因子。结果癌旁组织中PHF2阳性表达率(104/121,86.00%)高于癌组织(26/121,21.49%),差异有统计学意义(P<0.05)。PHF2阳性表达与年龄、性别、吸烟史、饮酒史无关(P>0.05),而与肿瘤直径、病理分级、血清HBsAg、肝硬化有关(P<0.05)。PHF2阴性表达病人平均生存时间为(16.24±2.11)个月,阳性表达为(21.29±2.18)个月,两组比较差异有统计学意义(P<0.05)。PHF2表达水平是影响肝细胞癌病人预后的独立危险因子。结论肝细胞癌病人组织中PHF2表达与临床病理特征及预后有关,其阴性表达不利于预后。Objective To investigate the relationship of plant homeodomain finger protein 2(PHF2)expression with clinicopathological features and prognosis in hepatocellular carcinoma.Methods 121 patients with hepatocellular carcinoma in our hospital from January 2015 to January 2019 were enrolled,their hepatocellular carcinoma tissues and para-carcinoma tissues were taken,and their clinical data were collected.PHF2 expression in cancer tissues was detected,and 3-year survival time was recorded.Then the correlation of PHF2 expression with clinicopathological parameters and prognosis of patients with hepatocellular carcinoma was discussed.Multivariate Cox regression was used to analyze the prognostic risk factors of hepatocellular carcinoma.Results The positive expression rate of PHF2 in adjacent normal tissues(104/121,86.00%)was significantly higher than that in cancer tissues(26/121,21.49%)(P<0.05).PHF2 positive expression was not associated with age,gender,smoking history,or alcohol consumption history(P>0.05),while was associated with tumor diameter,pathological grade,serum hepatitis B surface antigen(HBsAg)and cirrhosis(P<0.05).The mean survival time for patients with negative PHF2 expression was(16.24±2.11)months,which was significantly shorter than the patients with positive PHF2 expression[(21.29±2.18)months,P<0.05].PHF2 expression level was an independent risk factor affecting the prognosis of patients with hepatocellular carcinoma.Conclusion The expression of PHF2 in hepatocellular carcinoma is associated with clinicopathological features and prognosis,and patients with negative expression may suffer a poor prognosis.

关 键 词：肝细胞癌 PHF2 预后 

分 类 号：R735.7[医药卫生—肿瘤]