盐酸托莫西汀对注意缺陷多动障碍患儿认知加工过程的影响  

Influence of tomoxetine hydrochloride on the cognitive processing of children with attention deficit hyperactivity disorder

作　　者：王丹 秦岭[1] 刘海润[1] 李丹丹[1] 姚春玲 傅燕虹[1] 张鸿[1] 黄思艳 Wang Dan;Qin Ling;Liu Hairun;Li Dandan;Yao Chunling;Fu Yanhong;Zhang Hong;Huang Siyan(Center for Cognitive and Sleep,People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院认知睡眠中心,南宁530021

出　　处：《中华行为医学与脑科学杂志》2022年第9期819-825,共7页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：广西科学研究与技术开发计划课题(桂科攻)(1355005-5-5)。

摘　　要：目的研究盐酸托莫西汀对注意缺陷多动障碍(attention deficit hyperactivity disorder, ADHD)儿童认知加工过程的影响。方法 2018年1月至2021年7月, 选取62例确诊ADHD并首次接受盐酸托莫西汀治疗(8±4)周的ADHD患儿为ADHD组, 选取62例年龄与性别相匹配的健康儿童为健康对照组, 采用Das-Naglieri认知评估系统(Das-Naglieri:cognitive assessment system, DN:CAS)对ADHD组儿童和健康对照组儿童在治疗前、治疗后分别进行认知加工过程测验, 并分别比较ADHD组在接受盐酸托莫西汀治疗前及治疗后与健康对照组认知加工过程的差异, 同时比较ADHD组儿童自身在接受治疗前后的认知加工过程的差异。采用SPSS 26.0统计软件进行统计分析。ADHD组治疗前后评分比较使用配对样本t检验, ADHD组治疗前后与健康对照组评分比较使用独立样本t检验。结果 (1)与健康对照组相比, ADHD组治疗前DN:CAS测验中的计划分测验[(18.77±5.92)分, (28.56±5.55)分]、注意分测验[(22.24±5.93)分, (29.56±6.16)分]、同时性加工分测验[(34.21±7.75)分, (37.61±6.29)分]、继时性加工分测验[(30.37±7.12)分, (33.74±5.43)分]及总分[(105.60±21.29)分, (134.84±22.87)分]的量表分均降低, 均差异有统计学意义(t=9.49, 6.74, 2.68, 2.96, 7.36, 均P<0.05);ADHD组治疗后DN:CAS测验中的计划分测验[(22.13±5.99)分]、注意分测验[(25.26±7.11)分]仍低于健康对照组, 均差异有统计学意义(t=6.20, 3.60, 均P<0.05), 而同时性加工分测验、继时性加工分测验与健康对照组相比均差异无统计学意义(均P>0.05)。与治疗前相比, ADHD组治疗后DN:CAS测验中的计划分测验、同时性加工分测验、注意分测验、继时性加工分测验及总分的量表分均提高, 均差异有统计学意义(t=-6.03, -4.13, -4.77, -5.48, -8.59, 均P<0.05)。(2)与健康对照组相比, ADHD组治疗前DN:CAS测验中的数字匹配等9个小测验量表分均降低, 均差异有统计学意义(Objective To explore the influence of tomoxetine hydrochloride on the cognitive processing of children with attention deficit hyperactivity disorder(ADHD).Methods From January 2018 to July 2021,62 ADHD children who were treated with tomoxetine hydrochloride for the first time for(8±4)weeks were selected as the ADHD group.And 62 healthy children matched with age and sex were selected as the healthy control group.Pre-test and post-test by the Das-Naglieri:Cognitive Assessment System(DN:CAS)were performed to evaluate the cognitive function of all individuals.The differences of cognitive processing in pre-treatment and post-treatment of ADHD group were compared with those in healthy control group.The difference between before and after treatment of ADHD group was also compared.SPSS 26.0 statistical software was adopted for statistical analysis.The scores of ADHD group pre-treatment and post-treatment were compared by paired sample t-test,and the scores of ADHD group pre-treatment and post-treatment were compared with those of healthy control group by independent sample t-test.Results Compared with healthy control group,there were lower of planning score((18.77±5.92)vs(28.56±5.55)),attention score((22.24±5.93)vs(29.56±6.16)),simultaneous processing((34.21±7.75)vs(37.61±6.29)),successive processing((30.37±7.12)vs(33.74±5.43)),and the total scores((105.60±21.29)vs(134.84±22.87))in ADHD group before treatment,and there were significant differences(t=9.49,6.74,2.68,2.96,7.36,all P<0.05).Compared with healthy control group,there were lower of planning score((22.13±5.99)s),attention score((25.26±7.11)with significant difference(t=6.20,3.60,both P<0.05)in ADHD group after treatment.And there was no significant difference in the simultaneous processing test and the successive processing test after treatment compared with the healthy control group(both P>0.05).In ADHD group,the scores of planning,simultaneous processing,attention,successive processing and the total score were significantly higher after treatment t

关 键 词：盐酸托莫西汀 Das-Naglieri认知评估系统 注意缺陷多动障碍 认知加工过程 

分 类 号：R749.94[医药卫生—神经病学与精神病学]