“从脾论治”失眠在阿尔茨海默病中的研究进展  

Research advances in“Cure from the Spleen”for insomnia in patients with Alzheimer′s disease

作　　者：张福强 李鹤[1] 陈仁波[1] ZHANG Fu-Qiang;LI He;CHEN Ren-Bo(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中华老年多器官疾病杂志》2022年第12期914-917,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家重点研发计划(2018YFC1315200);中央级公益性科研院所基本科研业务费专项资金(Z0739)。

摘　　要：全球范围内老龄化加剧,包括痴呆在内的老年健康问题日益突出,其中阿尔茨海默病(AD)患者日益增多。AD本质上是神经炎症,与睡眠和免疫功能密切相关,失眠能诱发炎症反应,破坏肠道菌群丰度及多样性,最终促进该病发生发展。由于目前关于AD的发病机制尚不明确,西药治疗效果比较令人失望,可利用“脑肠轴”理论与中医学“百病皆由脾胃衰而生”理念的一致性和相关性,“从脾论治”失眠以重塑肠道菌群,有助于防治AD。Aging is increasing all over the world,and the health problems in the elderly,including dementia,are becoming increasingly prominent,with an increasing number of patients with Alzheimer′s disease(AD).AD essentially,is a condition of neuroinflammation,and is closely related to sleep and immune function,while,insomnia can induce an inflammatory response,destroy the abundance and diversity of intestinal flora,and ultimately promote the development of the disease.Since the pathogenesis of AD is still unclear,the therapeutic effect of Western medicine is relatively disappointing.Here,based on the consistency and correlation between the“Cerebrointestinal axis”theory and the concept of“all diseases are born from spleen and stomach failure”in Traditional Chinese Medicine,we discuss to“Cure from the Spleen”for insomnia so as to reshape the gut microbiota and thus be beneficial to prevent and treat AD.

关 键 词：阿尔茨海默病 肠道菌群 失眠 从脾论治 中医药疗法- 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R259[医药卫生—临床医学]