疏通降逆贴穴位敷贴联合口服奥美拉唑肠溶胶囊治疗胃食管反流病的疗效观察  

Clinical Observation of Shutongjiangni Acupoint Application Combined with Oral Omeprazole Enteric-coated Capsulesin the Treatment of Gastroesophageal Reflux Disease

作　　者：孙刚 刘万里[1] 杨璐[1] 王光铭[1] SUN Gang;LIU Wan-li;YANG Lu;WANG Guang-ming(Department of Spleen and Stomach,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Nanjing University of Chinese Medicine,Nanjing Jiangsu 210014)

机构地区：[1]南京中医药大学附属南京市中西医结合医院脾胃病科,江苏南京210014

出　　处：《世界中西医结合杂志》2022年第11期2269-2272,2277,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：南京市医学科技发展项目(YKK17190)。

摘　　要：目的观察疏通降逆贴穴位敷贴联合口服奥美拉唑肠溶胶囊治疗胃食管反流病的临床疗效。方法选取2018年1月—2020年1月期间南京中医药大学附属南京市中西医结合医院脾胃病科门诊收治的60例胃食管反流病(肝胃不和证)患者,依据随机数字分配原则将其分为对照组和观察组,每组各30例。对照组给予单纯口服奥美拉唑肠溶胶囊治疗,观察组在其基础上联合应用疏通降逆贴穴位贴敷。治疗8周后,观察比较两组患者治疗有效率(证候疗效、胃镜疗效),治疗前后中医证候积分和主要症状(反酸、胃灼热、反流及非心源性胸痛)积分。结果治疗后观察组证候疗效93.33%(28/30)高于对照组80.00%(24/30),差异有统计学意义(P<0.05)。治疗后观察组胃镜疗效90.00%(27/30)高于对照组76.67%(23/30),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候积分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者主要症状积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组主要症状积分较对照组明显降低,差异有统计学意义(P<0.05)。结论胃食管反流病治疗中联合应用疏通降逆贴穴位敷贴和奥美拉唑肠溶胶囊具有明显优势,提高疗效的同时可进一步缓解症状,有利于预后水平的提升。Objective To explore the effect of acupoint application of Shutong Jiangni Plaster combined with Omeprazole Enteric-coated Capsules in the treatment of gastroesophageal reflux disease.Methods A total of 60 patients with gastroesophageal reflux disease(liver-stomach disharmony syndrome)who were treated in the Outpatient Department of Department of Spleen and Stomach,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Nanjing University of Chinese Medicine from January 2018 to January 2020 were included and classified into control group(n=30)and observation group(n=30)according to the principle of random number allocation.The control group was treated with oral Omeprazole Enteric-coated Capsules alone,and the observation group with oral Omeprazole Enteric-coated Capsules and acupoint application of Shutong Jiangni Plaster.The treatment lasted eight weeks for both groups.The effective rate(effect on syndrome,gastroscopy result),traditional Chinese medicine(TCM)syndrome score,and scores of main symptoms(sour regurgitation,heartburn,reflux,and non-cardiogenic chest pain)were compared between the two groups.Results After treatment,in terms of syndrome alleviation,the effective rate in the observation group was 93.33%(28/30),which was higher than the 80.00%(24/30)in the control group(P<0.05).As for the relief of gastroscopy result,the effective rate in the observation group was 90.00%(27/30),as compared with the 76.67%(23/30)in the control group(P<0.05).After treatment,the TCM syndrome score was lower than that before treatment in the two groups(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05).After treatment,the scores of main symptoms were lower than those before treatment in the two groups(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).Conclusion In the treatment of gastroesophageal reflux disease,the combination of Shutong Jiangni Plaster and Omeprazole Enteric-coated Capsules has obvious advantages,wh

关 键 词：胃食管反流病 疏通降逆贴 奥美拉唑肠溶胶囊 

分 类 号：R571[医药卫生—消化系统] R573[医药卫生—内科学]