脐带间充质干细胞外泌体在肿瘤治疗中的研究进展  

Research progress of umbilical cord mesenchymal stem cell-derived exosomes in treatment of tumor

作　　者：李香影 刚乔健 牟力圆 盛英达 哈小琴 LI Xiangying;GANG Qiaojian;MU Liyuan;SHENG Yingda;HA Xiaoqin(School of Public Health of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu,730000;the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,Lanzhou,Gansu,730050;Key Laboratory of Stem Cell and Gene Medicine of Gansu Province,Lanzhou,Gansu,730050;the Second Clinical Medical School of Lanzhou University,Lanzhou,Gansu,730000)

机构地区：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000 [2]解放军联勤保障部队第九四〇医院,甘肃兰州730050 [3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050 [4]兰州大学第二临床医学院,甘肃兰州730000

出　　处：《实用临床医药杂志》2022年第23期108-112,118,共6页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(81273568);甘肃省拔尖领军人才培养项目(2020808);兰州市人才创新创业项目(2016-RC-61)。

摘　　要：脐带间充质干细胞是一种来自脐带的具有多向分化潜能的干细胞,可通过外泌体介导抑制肿瘤发展。脐带间充质干细胞外泌体可能通过参与免疫反应、抑制肿瘤细胞的增殖和侵袭、减少血管生成、提高药物敏感性等方式发挥抗肿瘤作用。但目前国内外关于脐带间充质干细胞外泌体用于肿瘤治疗的研究较少,本文对其在肿瘤治疗中的作用机制和应用前景进行综述。Umbilical cord mesenchymal stem cells are multidirectional stem cells from the umbilical cord that can inhibit tumor development through exosomes.Exosomes secreted by umbilical cord mesenchymal stem cells play an anti-tumor role by participating in immune response,inhibiting tumor cell proliferation,reducing angiogenesis and improving drug sensitivity.However,there are few studies on the application of exosomes secreted by umbilical cord mesenchymal stem cells in tumor therapy.The paper reviewed the mechanism of action and application prospect of these drugs in tumor therapy.

关 键 词：脐带间充质干细胞 外泌体 肿瘤 治疗 药物递送 

分 类 号：R730.5[医药卫生—肿瘤] R459.9[医药卫生—临床医学]