皮肤创面愈合中血管生成素样蛋白4的作用及机制的研究进展  

Research progress on role and mechanism of angiopoietin-like protein 4 in skin wound healing

作　　者：杨元 俞程浩 左睿 刘喆[2] 傅奕[3] 侯瑞兴[1] YANG Yuan;YU Chenghao;ZUO Rui;LIU Zhe;FU Yi;HOU Ruixing(Suzhou Ruihua Orthopedic Hospital of Teaching Hospital of Medical College of Yangzhou University,Suzhou,Jiangsu,215104;Suzhou Medical College of Soochow University,Suzhou,Jiangsu,215123;School of Biology&Basic Medical Sciences of Soochow University,Suzhou,Jiangsu,215123)

机构地区：[1]扬州大学医学院教学医院苏州瑞华骨科医院,江苏苏州215104 [2]苏州大学苏州医学院,江苏苏州215123 [3]苏州大学基础医学与生物科学学院,江苏苏州215123

出　　处：《实用临床医药杂志》2022年第23期134-137,142,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省研究生科研创新计划项目(KYCX21_3290);江苏省苏州市医疗卫生科技创新-应用基础研究项目(SKJY2021022)。

摘　　要：皮肤作为人体的第一道防线,常因物理性、机械性、生物性、化学性等因素而发生损伤。皮肤创面愈合是一个复杂的过程,包括各种组织的再生、肉芽组织增生以及瘢痕组织形成,且各个过程相互协同。血管生成素样蛋白4(ANGPTL4)是一种多功能细胞因子,在人体各组织中广泛表达。在伤口愈合过程中,ANGPTL4不仅可以影响炎症反应的进程,而且能促进角质细胞的迁移和分化、内皮细胞的增生以及减少瘢痕相关胶原的表达。因此,ANGPTL4在皮肤愈合的炎症期和增殖期发挥着重要的作用。本研究对ANGPTL4在皮肤创面愈合中的作用及机制进行综述。The skin, as the first line of defense in the human body, is often damaged by physical, mechanical, biological, chemical and other factors. The skin wound healing is a complex process, including the regeneration of various tissues, proliferation of granulation tissues and formation of scar tissues, and all the processes show synergism with each other. Angiopoietin-like protein 4(ANGPTL4) is a multifunctional cytokine that is widely expressed in various human tissues. In the process of wound healing, ANGPTL4 not only affects the process of inflammatory response, but also promotes the migration and differentiation of keratinocytes, the proliferation of endothelial cells and the reduction of the expression of scar-related collagen. Therefore, ANGPTL4 plays an important role in the inflammatory and proliferative phases of skin healing. This paper summarizes the function and mechanism of ANGPTL4 in skin wound healing.

关 键 词：血管生成素样蛋白4 皮肤创面愈合 炎症反应 再上皮化 炎症期 增殖期 

分 类 号：R641[医药卫生—外科学] R622[医药卫生—临床医学]