生物节律基因NPAS2在肿瘤中的研究  

The Study of Biological Rhythm Gene NPAS2 in Tumors

作　　者：曹小萌 夏天红 袁绍斌 阎龙 刘宏斌 CAO Xiao-meng;XIA Tian-hong;YUAN Shao-bin;YAN Long;LIU Hong-bin(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Department of General Surgery,The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]解放军联勤保障部队第九四〇医院普通外科,甘肃兰州730050

出　　处：《医学信息》2022年第24期164-168,共5页Journal of Medical Information

基　　金：国家科技部、财政部惠民计划项目(编号:2012GS620101);甘肃省自然科学基金项目(编号:21JR1RA186)。

摘　　要：生物节律是一种时间跟踪节律性生物系统,生物节律基因调节2%~10%的基因表达,使生物体能够预测环境变化并作出行为和生理功能的反应。神经元PAS结构域蛋白2(NPAS2)作为目前发现的最大的生物节律基因,可控制和调节睡眠、觉醒、内分泌、代谢、细胞增殖和凋亡以及免疫系统等过程,参与哺乳动物昼夜节律的周期调控,对于生理内环境稳定的维持至关重要。NPAS2功能的破坏可导致各种病理过程及疾病的产生,例如糖尿病、抑郁症、心血管问题,尤其可影响多种癌症的发生发展及预后。本文对生物节律基因NPAS2进行概述,并对其在生物节律调控中的作用以及在各类疾病尤其在肿瘤发生发展中的作用进行综述。Biorhythm is a time-tracking biological system in which biorhythm genes regulate 2%-10%of gene expression,enabling organisms to predict environmental changes and respond to behavioral and physiological functions.Neuronal PAS domain protein 2(NPAS2),as the largest biorhythm gene discovered so far,controls and regulates sleep/wake,endocrine,metabolism,cell proliferation and apoptosis,and immune system,and participates in the periodic regulation of circadian rhythms in mammals,which is crucial for the maintenance of physiological internal environment stability.The destruction of NPAS2 function can lead to various pathological processes and diseases,such as diabetes,depression,cardiovascular problems,especially affecting the occurrence,development,and prognosis of various cancers.This article summarizes the biological rhythm gene NPAS2,and reviews its role in the regulation of biological rhythm and its role in various diseases,especially in the development of tumors.

关 键 词：生物节律 神经元PAS结构域蛋白2 肿瘤 生理功能 

分 类 号：R730.231[医药卫生—肿瘤]