中药序贯治疗视神经脊髓炎谱系疾病临床观察  

Efficacy observation of sequential therapy of traditional Chinese medicine on neuromyelitis optica spectrum disorders

作　　者：全伟[1] QUAN Wei(Linyi Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine,Linyi 276000,China)

机构地区：[1]山东中医药大学附属临沂市中医医院,临沂276000

出　　处：《山西中医》2023年第1期33-35,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：山东省临沂市医疗卫生科技发展计划项目(编号:201919035)。

摘　　要：目的:观察中药序贯治疗视神经脊髓炎谱系疾病的疗效。方法:回顾性分析视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders,NMOSD)患者的临床资料,其中25例予激素联合中药序贯治疗(治疗组),20例予激素治疗(对照组),分别于治疗前及大剂量激素阶段、中等剂量激素阶段及小剂量激素阶段,采用扩展残疾状态量表(EDSS)对患者病情进行评估,并记录两组用药过程中发生的激素相关不良反应情况。结果:两组治疗后各阶段的EDSS评分均低于治疗前(校正P<0.05)。治疗组在大剂量激素阶段的EDSS评分与对照组比较无统计学差异(P>0.05),在中等激素剂量阶段和小剂量激素阶段的EDSS评分低于对照组(P<0.05)。治疗组激素相关不良反应的发生率低于对照组(P<0.05),具体为医源性库欣综合征的发生率低于对照组(P<0.05)。结论:中药序贯治疗NMOSD能改善患者的后遗症状,预防激素相关不良反应。Objective:To observe the clinical efficacy of sequential therapy of traditional Chinese medicine on neuromyelitis optica spectrum disorders(NMOSD).Methods:The clinical data of patients with neuromyelitis optica spectrum disorders were analyzed retrospectively.Among them,25 cases of treatment group were treated with hormone and by sequential therapy of traditional Chinese medicine,while 20 cases of control group were treated with hormone alone.The patients’conditions were evaluated by Expanded Disability Status Scale(EDSS)respectively before treatment,in the stage of large dose hormone,in the stage of medium dose hormone and in the stage of small dose hormone.The hormone-related adverse reactions in course of medication were recorded in two groups.Results:In each stage after treatment,in two groups,EDSS scores were lower than those before treatment(corrected P<0.05).There was no statistical difference between treatment group and control group in EDSS score in the stage of large dose hormone(P>0.05);but EDSS score of treatment group was lower than that of control group in the stages of medium-and smalldose hormone(P<0.05).The incidence of hormone-related adverse reactions in treatment group was lower than that in control group(P<0.05);specifically,the incidence of iatrogenic Cushing’s syndrome in treatment group was lower than that in control group(P<0.05).Conclusion:The sequential therapy of traditional Chinese medicine for treatment of NMOSD can improve the sequela of patients,and prevent the hormone-related adverse reactions.

关 键 词：视神经脊髓炎谱系疾病 激素 中药序贯疗法 

分 类 号：R744.52[医药卫生—神经病学与精神病学]