精神分裂症组蛋白修饰与神经递质系统关系的多组学研究  

Multi-omics Study of the Relationship Between Histone Modification and Neurotransmitter System in Schizophrenia

作　　者：闻祎韡 宋炜宸 WEN Yiwei;SONG Weichen(Shanghai Jiao Tong University,School of BME,Shanghai 200030,China)

机构地区：[1]上海交通大学生物医学工程学院,上海200030

出　　处：《生物医学工程学进展》2022年第4期219-222,共4页Progress in Biomedical Engineering

摘　　要：目的探索组蛋白修饰通过神经递质系统影响精神分裂症发病风险的途径。方法利用WGCNA软件包对精神分裂症患者脑表达谱建立的组蛋白-神经递质间的基因共表达网络,分析患者和健康对照组是否在组蛋白-神经递质的关联关系上存在差异。结果患者大脑中组蛋白-神经递质系统相关性显著降低。结论通过辨别网络中疾病差异表达和新发突变的核心组蛋白修饰基因的分布,该研究发现CALM2、PRKAR1A、CAPZA2、BSN、GRIN1、LRFN3六个候选基因可能是精神分裂症遗传风险的关键基因。Objective To explore the pathway through which histone modification affects the risk of schizophrenia through the neurotransmitter system.Methods To use the WGCNA package to establish the gene co-expression network between histone and neurotransmitter in the brain expression profiles of patients with schizophrenia,to analyze whether there are differences in histone-neurotransmitter associations between patients and healthy controls.Results The correlation of histone-neurotransmitter system in the patient's brain was significantly reduced.Conclusion By identifying the distribution of core histone-modifying genes with differential expression and newly mutated core histones in the network,we found CALM2,PRKAR1A,CAPZA2,BSN,GRIN1,LRFN3 Six candidate genes may be key genes for genetic risk of schizophrenia.

关 键 词：精神分裂症 组蛋白 神经递质系统 CALM2 风险基因 

分 类 号：R749[医药卫生—神经病学与精神病学]