Ⅲ期黑色素瘤围手术期治疗的现状与展望  

Current status and prospect of perioperative treatment of stageⅢmelanoma

作　　者：徐宇 陈勇 杨吉龙 朱冠男 XU Yu;CHEN Yong;YANG Jilong;ZHU Guannan(Department of Musculoskeletal Surgery,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Departments of Bone and Soft Tissue Tumor,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin 300060,China;Tianjin’s Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Key Laboratory of Molecular Cancer Epidemiology,Tianjin 300060,China;Department of Dermatology,Xijing Hospital,Air Force Military Medical University(Fourth Military Medical University),Xi’an 710032,Shaanxi Province,China)

机构地区：[1]复旦大学附属肿瘤医院骨软组织外科,复旦大学上海医学院肿瘤学系,上海200032 [2]天津医科大学肿瘤医院骨与软组织肿瘤科,国家恶性肿瘤临床医学研究中心,天津300060 [3]天津市恶性肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津市肿瘤分子流行病重点实验室,天津300060 [4]空军军医大学(第四军医大学)西京皮肤医院,陕西西安710032

出　　处：《中国癌症杂志》2022年第12期1133-1146,共14页China Oncology

基　　金：国家自然科学基金(82172607,82272857,81802636);临港实验室基金(LG-QS-202205-11);上海市科学技术委员会科研计划(19411951700)。

摘　　要：黑色素瘤是一种恶性程度极高的肿瘤,早期黑色素瘤经手术切除多可治愈,但对于高危型病例(ⅡB~Ⅳ期),辅助治疗是延长患者生命、改善预后的重要手段。近年来随着系统治疗药物的蓬勃发展,对于Ⅲ期可切除病例的围手术期治疗理念不断发生变化。本文着眼于外科手术规范及对预后的影响、术后辅助治疗选择、新辅助治疗的进展等热点问题进行梳理,并结合来源于中国患者的治疗数据进行分析讨论,希望为中国Ⅲ期黑色素瘤的围手术期治疗选择提供新的思路。Melanoma is one of the most dangerous tumors due to its high-grade malignancy.Though patients in early stage can be completely cured by surgery,for high-risk cases(stageⅡB-Ⅳ),adjuvant therapy is of great importance to prolong the survival and improve the prognosis.In recent years,thanks to the booming development of systemic regimen,the perioperative managements for stageⅢcases have been continuously evolving.In the current paper,we focused on the role of lymph node biopsy and surgical resection,postoperative adjuvant therapy options,as well as the cutting-edge neoadjuvant therapy development,aiming to provide new perioperative strategies for stageⅢmelanoma patients.

关 键 词：黑色素瘤 围手术期治疗 辅助治疗 新辅助治疗 

分 类 号：R739.5[医药卫生—肿瘤]