Toll样受体相关疾病研究进展  

Research Progress of Toll-like Receptor Related Diseases

作　　者：杨宏鹏 张首国 曹莹 彭涛 温晓雪 王林[1,2,3] 胡利明 YANG Hong-peng;ZHANG Shou-guo;CAO Ying;PENG Tao;WEN Xiao-xue;WANG Lin;HU Li-ming(Faculty of Environment&Life,Beijing University of Technology,Beijing 100124,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China;College of Pharmacy,Anhui Medical University,Hefei 230032,China)

机构地区：[1]北京工业大学环境与生命学部,北京100124 [2]军事科学院军事医学研究院辐射医学研究所,北京100850 [3]安徽医科大学药学院,合肥230032

出　　处：《科学技术与工程》2022年第35期15427-15435,共9页Science Technology and Engineering

基　　金：国家自然科学基金(21102176,21272273)。

摘　　要：Toll样受体(Toll-like receptors, TLRs)家族存在于所有活的多细胞生物中。研究表明,TLRs在对机体天然免疫、识别病原体方面包括感染性、自身免疫性、过敏性、炎症和癌症在内的多种疾病的发病机制中发挥了非常重要的作用。简要介绍了TLRs家族受体相关的常见疾病,结合已有的成果对相关疾病相关受体的研究方法及应用现状进行阐述。最后,对Toll样受体为人类克服相关疾病的未来发展方向进行展望。Toll-like receptors family exists in all living multicellular organisms. Studies have shown that they play very important role in the pathogenesis of a variety of diseases, including infectious, autoimmune, allergic, inflammatory and cancer. Common diseases related to TLRs family receptors were briefly introduced. The research methods and application status of related receptors of related diseases were described in combination with the existing achievements. Finally, the future development direction of Toll-like receptor in overcoming related diseases was looked forward.

关 键 词：TOLL样受体 疾病 研究方法 应用现状 

分 类 号：R914.5[医药卫生—药物化学]