眼表微环境与泪膜稳态对视觉质量影响的新认识  

New Understanding of the Influence of Ocular Surface Microenvironment and Tear Film Homeostasis on Visual Quality

作　　者：林琳[1] 冯云[2] 傅瑶[3] 高华 顾正宇[5] 郭年波 洪佳旭 胡亮 黄晓丹[1] 接英[9] 晋秀明[1] 柯碧莲[10] 李贵刚[11] 李炜[12] 陆成伟[13] 潘志强[9] 王辉[14] 王林农[15] 吴洁 徐建江 张弘 张运江 周文天[19] 曾庆延[20] Lin Lin;Yun Feng;Yao Fu;Hua Gao;Zhengyu Gu;Nianbo Guo;Jiaxu Hong;Liang Hu;Xiaodan Huang;Ying Jie;Xiuming Jin;Bilian Ke;Guigang Li;Wei Li;Chengwei Lu;Zhiqiang Pan;Hui Wang;Linnong Wang;Jie Wu;Jianjiang Xu;Hong Zhang;Yunjiang Zhang;Wentian Zhou;Qingyan Zeng(Department of Ophthalmology,the Second Affliated Hospital of Zhejiang University School of Medicine,Hangzhou 310003,China;Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China;Department of Ophthalmology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 20001l,China;Eye Hospital of Shandong First Medical University,Jinan 250299,China;Department of Ophthalmology,the First Affliated Hospital of Anhui Medical University,Hefei 230022,China;Ganzhou Qi Ming Xing Eye Hospital,Ganzhou 341001,China;Department of Ophthalmology,Fudan University Affliated Eye,Ear,Nose and Throat Hospital,Shanghai 200126,China;EyeHospital,Wenzhou Medical University,Wenzhou325027,China;Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing 100005,China;Department of Ophthalmology,Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430030,China;Eye Institute of Xiamen University,Xiamen 361104,China;Department of Ophthalmology,the First Hospital of Jilin University,Changchun 130031,China;Department of Ophthalmology,the First Affiliated Hospital of Gannan Medical College,Ganzhou 341001,China;Department of Ophthalmology,Nanjing Hospital Affliated to Nanjing Medical University,Nanjing 210006,China;Department of Ophthalmology,Xi'an No.1 People's Hospital,Xi'an 710002,China;Department of Ophthalmology,the First Affiliated Hospital of Harbin Medical University,Harbin 150007,China;Jian Kangming Eye Hospital,Ji'an 343099,China;Afiliated Eye Hospital of Nanchang University,Nanchang 330006,China;Wuhan Aier Hankou Eye Hospital,Wuhan 430064,C

机构地区：[1]浙江大学医学院附属第二医院眼科,杭州310003 [2]北京大学第三医院眼科,北京100191 [3]上海交通大学医学院附属第九人民医院眼科,上海200011 [4]山东第一医科大学附属眼科医院,济南250299 [5]安徽医科大学第一附属医院眼科,合肥230022 [6]赣州启明星眼科医院,赣州341001 [7]复旦大学附属眼耳鼻喉科医院眼科,上海200126 [8]温州医科大学附属眼视光医院,温州325027 [9]首都医科大学附属北京同仁医院眼科中心,北京100005 [10]上海交通大学医学院附属第一人民医院眼科,上海200080 [11]华中科技大学同济医学院附属同济医院眼科,武汉430030 [12]厦门大学眼科研究所,厦门361104 [13]吉林大学第一医院眼科,长春130031 [14]赣南医学院第一附属医院眼科,赣州341001 [15]南京医科大学附属南京医院眼科,南京210006,西 [16]安市第一医院眼科,西安710002 [17]哈尔滨医科大学附属第一医院眼科,哈尔滨150007 [18]吉安康明眼科医院,吉安343099 [19]南昌大学附属眼科医院,南昌330006 [20]武汉爱尔眼科医院汉口医院,武汉430064

出　　处：《中华眼视光学与视觉科学杂志》2022年第12期881-887,共7页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：2020年发布的中国干眼专家共识第一次将眼表微环境的概念新增到了干眼的定义中。强调了泪膜不稳定和眼表微环境失衡在干眼发病机制中的重要地位,并将视功能障碍作为干眼病情发展的重要结局之一。为了加强对新共识的认识,推动相关的基础与临床研究的开展及转化,为广大干眼患者提供更为细致的诊疗建议,专家组于2021年3年26日在江西吉安召开讨论会,对眼表微环境和泪膜稳态这两方面的研究现状及存在的问题进行分析,主要围绕干眼的这两个核心机制的新认识、与视觉质量的关系、临床的评估和治疗手段的建议和未来发展新方向等提出建议和推荐意见。The Chinese Dry Eye Expert Consensus released in 2020 added the concept of ocular surface microenvironment to the definition of dry eye for the first time.The tear film instability and ocular surface microenvironmental imbalance was emphasized to play a critical role in the pathogenesis of dry eye,and visual dysfunction was defined as one of the important outcomes of dry eye.In order to strengthen the understanding of the new consensus,promote the development and transformation of related basic and clinical research,and provide more detailed diagnosis and treatment recommendations for dry eye patients,many experts in the field of dry eye held a panel discussion in Ji'an on March 26,2021 and analyzed the current research status and existing problems of the ocular surface microenvironment and tear film homeostasis.In that meeting,opinions and recommendations were put forward based on new understandings of the two key factors in the mechanism of dry eye,the relationship with visual quality,clinical methods of evaluation and treatment,and new directions for future development.

关 键 词：微环境 泪膜 视觉质量 推荐意见 

分 类 号：R777.34[医药卫生—眼科]