局部复发直肠癌的新辅助治疗  

Progress of neoadjuvant therapy for locally recurrent rectal cancer

作　　者：黄骁 项建斌[1] Xiao Huang;Jianbin Xiang(Department of General Surgery,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院普通外科,200040

出　　处：《中华结直肠疾病电子杂志》2022年第6期452-458,共7页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金面上项目(82172705)。

摘　　要：随着医疗科技和手术方式的进步,直肠癌术后局部复发不再是外科手术的禁忌证,根治性切除后患者仍可获得良好的生存预后。但由于局部复发直肠癌(LRRC)R0切除率不高、远期生存有待改善,单纯手术切除并不适用于多数此类患者,且多脏器切除术后患者体弱、耐受性较差,接受辅助化/放疗机会不多,因此越来越多的学者关注LRRC的新辅助治疗,以期提高R0切除和改善远期效果。本文概述了LRRC新辅助治疗及其适应证、新辅助治疗联合腹腔热灌注治疗等的研究进展。With the advancement of medical technology and surgical techniques, postoperative recurrence of rectal cancer is no longer a contraindication of surgery, and patients can still obtain a great survival prognosis after radical resection. However, due to the low R0 resection rate of locally recurrent rectal cancer and the need to improve long-term survival, surgical resection alone is not suitable for most of these patients, and the patients after multiple-organ resection are frail, have poor tolerance, and have few opportunities to receive adjuvant chemotherapy/radiotherapy. Therefore, more and more scholars have added neoadjuvant therapy to the treatment of such patients. This article summarizes the research progress of neoadjuvant therapy and its indications, neoadjuvant therapy combined with hyperthermia for locally recurrent rectal cancer.

关 键 词：直肠肿瘤 复发 新辅助治疗 

分 类 号：R735.37[医药卫生—肿瘤]