谷胱甘肽在结直肠癌增殖转移及诊疗中的研究进展  

Research progress of glutathione in proliferation,metastasis and diagnosis and treatment of colorectal cancer

作　　者：刘成飞 徐少强 姚添 黄河[2] Chengfei Liu;Shaoqiang Xu;Tian Yao;He Huang(The First Clinical School,Shanxi Medical University,Taiyuan 030001,China;Department of Gastrointestinal Surgery,the First Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一医院胃肠外科,太原030001

出　　处：《中华结直肠疾病电子杂志》2022年第6期506-510,共5页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：山西省重点研发计划项目(201903D321155)。

摘　　要：全球范围内,结直肠癌是发病率和死亡率分别高居第三及第二位的恶性肿瘤。谷胱甘肽是生物体内抗氧化系统的重要成分。国内外研究证明谷胱甘肽在结直肠癌组织中水平异常增高,参与了结直肠癌细胞的氧化应激、铁死亡等方面,并具有成为结直肠癌治疗靶点的潜力。本文主要围绕谷胱甘肽在结直肠癌增殖转移及诊疗中的研究作一综述,阐述其在结直肠癌中的研究现状及应用前景。The morbidity and mortality of colorectal cancer rank second and third in malignancies around the globe, respectively. Glutathione is an important component of the antioxidant system in organisms. Studies in or outside China have shown that glutathione is abnormally increased in colorectal cancer tissues, and is involved in oxidative stress and ferroptosis of colorectal cancer cells, and has the potential to become a therapeutic target of colorectal cancer. In this paper, we have focused mainly on the studies of glutathione in the proliferation, metastasis, diagnosis and treatment of colorectal cancer, and elaborated its research status and application prospects in colorectal cancer.

关 键 词：结直肠肿瘤 谷胱甘肽 氧化应激 铁死亡 

分 类 号：R735.34[医药卫生—肿瘤]