KaKs_Calculator 3.0:Calculating Selective Pressure on Coding and Non-coding Sequences  

作　　者：Zhang Zhang 

机构地区：[1]National Genomics Data Center,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China [2]CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China [3]China National Center for Bioinformation,Beijing 100101,China [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Genomics, Proteomics & Bioinformatics》2022年第3期536-540,共5页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA19050302);the National Natural Science Foundation of China(Grant Nos.31871328 and 32030021);the National Key R&D Program of China(Grant No.2017YFC0907502);the International Partnership Program of the Chinese Academy of Sciences(Grant No.153F11KYSB20160008).

摘　　要：KaKs_Calculator 3.0 is an updated toolkit that is capable of calculating selective pressure on both coding and non-coding sequences.Similar to the nonsynonymous/synonymous substitution rate ratio for coding sequences,selection on non-coding sequences can be quantified as the ratio of non-coding nucleotide substitution rate to synonymous substitution rate of adjacent coding sequences.As testified on empirical data,KaKs_Calculator 3.0 shows effectiveness to detect the strength and mode of selection operated on molecular sequences,accordingly demonstrating its great potential to achieve genome-wide scan of natural selection on diverse sequences and identification of potentially functional elements at a whole-genome scale.The package of KaKs_Calculator 3.0 is freely available for academic use only at https://ngdc.cncb.ac.cn/biocode/tools/BT000001.

关 键 词：KaKs_Calculator Selective pressure SUBSTITUTION CODING NON-CODING 

分 类 号：Q811.4[生物学—生物工程]