NON-CODING

作品数:133被引量:539H指数:12
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相关领域:医药卫生生物学更多>>
相关作者:郑智捷孙树汉应晓敏李宗城张健更多>>
相关机构:第二军医大学信息科学与技术学院军事医学科学院空军军医大学(第四军医大学)更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas被引量:1
《Science China(Life Sciences)》2024年第9期2003-2015,共13页Simin Chai Yujie Chong Daiqing Yin Qiang Qiu Shixia Xu Guang Yang 
supported by the Youth Fund of the National Natural Science Foundation of China(32200345);China Postdoctoral Science Foundation(2022M710878);the National Natural Science Foundation of China(32270453,32270442,31772448);the Key Project of the National Natural Science Foundation of China(32030011);the PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2021GD0805)。
Jerboas is a lineage of small rodents displaying atypical mouse-like morphology with elongated strong hindlimbs and short forelimbs.They have evolved obligate bipedal saltation and acute senses,and been well-adapted t...
关键词:jerboa adaptive evolution comparative genomics conserved non-coding elements bipedal saltation 
Coding,or non-coding,that is the question
《Cell Research》2024年第9期609-629,共21页Laura Poliseno Martina Lanza Pier Paolo Pandolfi 
supported by ISPRO-Istituto per lo Studio,la Prevenzione e la Rete Oncologica(institutional funding to L.P.);It was also partially supported by AIRC-Associazione Italiana Ricerca sul Cancro(IG#25694 to L.P.);P.P.P.has been supported by the Renown Foundation and the PTEN Research Foundation.Cartoons created with BioRender.com.
The advent of high-throughput sequencing uncovered that our genome is pervasively transcribed into RNAs that are seemingly not translated into proteins.It was also found that non-coding RNA transcripts outnumber canon...
关键词:SHAKING PROMPT BECOMING 
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
《四川生理科学杂志》2024年第4期860-860,共1页Biola M Javierre 
Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation.The vast majority of interactions are uncharted,constituting a major missing link in understanding ge...
关键词:PROMOTER enriched INSIGHT 
NCAD v1.0: a database for non-coding variant annotation and interpretation
《Journal of Genetics and Genomics》2024年第2期230-242,共13页Xiaoshu Feng Sihan Liu Ke Li Fengxiao Bu Huijun Yuan 
supported by the National Natural Science Foundation of China(82171836);the 1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYJC20002).
The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. T...
关键词:Non-coding variants ANNOTATION Variant interpretation DATABASE 
Comparative phylogenomics and phylotranscriptomics provide insights into the genetic complexity of nitrogen-fixing root-nodule symbiosis
《Plant Communications》2024年第1期130-147,共18页Yu Zhang Yuan Fu Wenfei Xian Xiuli Li Yong Feng Fengjiao Bu Yan Shi Shiyu Chen Robin van Velzen Kai Battenberg Alison M.Berry Marco G.Salgado Hui Liu Tingshuang Yi Pascale Fournier Nicole Alloisio Petar Pujic Hasna Boubakri M.Eric Schranz Pierre-Marc Delaux Gane Ka-Shu Wong Valerie Hocher Sergio Svistoonoff Hassen Gherbi Ertao Wang Wouter Kohlen Luis G.Wall Martin Parniske Katharina Pawlowski Philippe Normand Jeffrey J.Doyle Shifeng Cheng 
supported by the National Natural Science Foundation of China (32022006);the Program for Guangdong"ZhuJiang"Innovation Teams (2019ZT08N628);the Agricultural Science and Technology Innovation Program (ASTIP) (CAAS-XTCX2016001);the special funds for science technology innovation and industrial development of Shenzhen Dapeng New District (PT202101-01);supported by the National Natural Science Foundation of China (32070250);the Natural Science Foundation of Guangdong Province (2020A1515011030);the open research project of"Cross-Cooperative Team"of the Germplasm Bank of Wild Species,Kunming Institute of Botany,Chinese Academy of Sciences;supported by the Natural Science Foundation of Guangdong Province (2022A1515110240);support was provided by IRD and the Agence Nationale de la Recherche (Project SESAM,2010 BLAN 170801).
Plant root-nodule symbiosis(RNS)with mutualistic nitrogen-fixing bacteria is restricted to a single clade of angiosperms,the Nitrogen-Fixing Nodulation Clade(NFNC),and is best understood in the legume family.Nodulatin...
关键词:nitrogen-fixing root-nodule symbiosis two competing hypotheses PHYLOGENOMICS phylotranscrip-tomics conserved non-coding elements convergence deep homology 
Identification of clade-wide putative cis-regulatory elements from conserved non-coding sequences in Cucurbitaceae genomes
《Horticulture Research》2023年第4期238-248,共11页Hongtao Song Qi Wang Zhonghua Zhang Kui Lin Erli Pang 
supported by the National Natural Science Foundation of China(grant number:31571361).
Cis-regulatory elements regulate gene expression and play an essential role in the development and physiology of organisms.Many conserved non-coding sequences(CNSs)function as cis-regulatory elements.They control the ...
关键词:elements CONSERVED SEQUENCES 
Developmental regulation of conserved non-coding element evolution provides insights into limb loss in squamates被引量:2
《Science China(Life Sciences)》2023年第10期2399-2414,共16页Zeng Wang Changjun Peng Wei Wu Chaochao Yan Yunyun Lv Jia-Tang Li 
the Strategic Priority Research Program of Chinese Academy of Sciences(XDB31000000);the National Natural Science Foundation of China(32220103004,32000296);the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0501);the International Partnership Program of Chinese Academy of Sciences(151751KYSB20190024);the Sichuan Science and Technology Program(2021JDJQ0002)。
Limb loss shows recurrent phenotypic evolution across squamate lineages.Here,based on three de novo-assembled genomes of limbless lizards from different lineages,we showed that divergence of conserved non-coding eleme...
关键词:squamates limb loss cis-regulatory elements early limb development 
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes被引量:3
《Science China(Life Sciences)》2023年第10期2437-2440,共4页Fengming Huang Xiangyu Qiao Song Mei Cong Zhang Chengyu Jiang 
the National Natural Science Foundation of China(81788101,32100104);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1022);the CAMS Endowment Fund(2021-CAMS-JZ001);the Overseas Expertise Introduction Center for Discipline Innovation(“111Center”)(BP0820029)。
Dear Editor,During the construction and analysis of the Bencao(herbal)small RNA(s RNA)Atlas,the fact that many s RNAs from the human genome are present in the Bencao(herbal)database attracted our attention(Cao et al.,...
关键词:HERBAL ATLAS 
The long non-coding RNA DANA2 positively regulates drought tolerance by recruitingERF84 to promote JMJ29-mediated histone demethylation被引量:2
《Molecular Plant》2023年第8期1339-1353,共15页Pengxiang Zhang Reqing He Jun Yang Jingjing Cai Zhipeng Qu Rongxin Yang Jinbao Gu Zhen-Yu Wang David LAdelson Youlin Zhu Xiaofeng Cao Dong Wang 
supported by the National Natural Science Foundation of China(grants 32070627 and 31960138 to D.W.,31800224 and 32160070 to R.H.,and 31788103 to X.C.);the Chinese Academy of Sciences(Strategic Priority Research Program XDB27030201 to X.C.);the Natural Science Foundation of Jiangxi Province(grant 20171ACB20001 to D.W.).
Tens of thousands of long non-coding RNAs have been uncovered in plants,but few of them have been comprehensively studied for their biological function and molecular mechanism of their mode of action.Here,we show that...
关键词:long NON-CODING RNA H3K9 DEMETHYLASE TRANSCRIPTION factor DROUGHT response 
The non-coding RNA SVALKA locus produces a cis-natural antisense transcript that negatively regulates the expression of CBF1 and biomass production at normal temperatures
《Plant Communications》2023年第4期77-87,共11页Vasiliki Zacharaki Shiv Kumar Meena Peter Kindgren 
funded by the Swedish Research Council(2018-03926);Carl Trygger Foundation(20:224).
Non-coding transcription is present in all eukaryotic genomes,but we lack fundamental knowledge about its importance for an organism’s ability to develop properly.In plants,emerging evidence highlights the essential ...
关键词:SVALKA cis-natural antisense transcript non-coding transcription CBF1 Arabidopsis 
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