DEMETHYLASE

作品数：87被引量：394H指数：11
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相关领域：医药卫生生物学更多>>
相关作者：孙莹璞何道航更多>>
相关机构：郑州大学第一附属医院郑州大学西北妇女儿童医院西南大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Overexpression of the apple m^(6)A demethylase gene MdALKBH1A regulates resistance to heat stress and fixed-carbon starvation
《Journal of Integrative Agriculture》2025年第4期1489-1502,共14页Ru Bao Tianli Guo Zehua Yang Chengyu Feng Junyao Wu Xiaomin Fu Liu Hu Changhai Liu Fengwang Ma 
supported by the earmarked fund for the China Agricultural Research System(CARS-27)。
The pivotal role of N^(6)-methyladenosine(m^(6)A)demethylases in regulating plant stress responses has been widely explored;however,the function of apple m^(6)A demethylases under heat stress and fixed-carbon starvati...
关键词：MdALKBH1A heat stress fixed-carbon starvation TOMATO APPLE 
Identification of chikusetsusaponin IVa as a novel lysine-specific demethylase 1 inhibitor that ameliorates high fat diet-induced MASLD in mice
《Acta Pharmacologica Sinica》2025年第3期632-652,共21页Yu-wen Liu Ru-yue Luo An-qi Liu Jia-wei Wang Na-ping Hu Wang-ting Li Jian-kang Li Jing-wen Wang Jia-lin Duan 
supported by the National Natural Science Foundation of China(81903832);Key Research and Development Plan of Shaanxi Province(2022SF-182);Fundamental Research Funds for the Central Universities(D5000210799);Shaanxi Provincial Traditional Chinese Medicine Administration“Double Chain Integration”Middle Youth Research and Innovation Team Project(2022-SLRH-LJ-007);Shanghai Science and Technology Innovation Action Plan(22S21902600).
Diet-induced metabolic dysfunction steatotic liver disease(MASLD)is also called as non-alcoholic fatty liver disease(NAFLD)with limited effective strategies available.We previously have shown that chikusetsusaponin IV...
关键词：MASLD chikusetsusaponin Iva LSD1 fatty acid oxidation FXR/SHP CREBH 
Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy
《Acta Pharmaceutica Sinica B》2024年第12期5382-5392,共11页Lu Liu Yuanlai Qiu Yuying Suo Siyao Tong Yiqing Wang Xi Zhang Liang Chen Yue Huang Huchen Zhou Hu Zhou Ze Dong Cai-Guang Yang 
supported by the National Natural Science Foundation of China(92153303 to Cai-Guang Yang and 22077133 to Ze Dong);the Research Funds of Hangzhou Institute for Advanced Study,UCAS(2023HIAS-Y026 and 2023HIAS-V006 to Ze Dong,China);the National Key Research and Development Program of China(2022YFC2601800 to Yue Huang);the Youth Innovation Promotion Association of CAS(2021277 to Ze Dong and 2020285 to Yue Huang,China);the Open Funding Project of State Key Laboratory of Microbial Metabolism(MMLKF22-10,China).
The fat mass and obesity-associated protein(FTO)is an RNA demethylase required for catalytic demethylation of N^(6)-methyladenosine(m^(6)A);it is highly expressed and functions as an oncogene in acute myeloid leukemia...
关键词：N^(6)-Methyladenosine FTO PROTAC RNA epigenetics Antileukemia 
Role of lysine-specific demethylase 1 in immunotherapy of gastric cancer:An update
《Chinese Journal of Cancer Research》2024年第6期669-682,共14页Yongjing Ren Yanan Gong Huan Zhao Duo You Zhifei Li Sai-Qi Wang Xiaobing Chen 
supported by Natural Science Foundation of Henan Province(No.232300421119);Henan Medical Science and Technique Foundation of Henan Province(No.SBGJ202301004);National Natural Science Foundation of China(No.82103560);Medical Science and Technique Foundation of Henan Province(No.SBGJ202302029);Young and Middle-aged Health Science and Technology Innovation Talent Training Program of Henan Province(No.YXKC2022048);Postdoctoral Research Funding Project of Henan Province(Postdoctoral No.339552)。
Gastric cancer(GC)ranks 3rd in incidence rate and mortality rate among malignant tumors in China,and the age-standardized five-year net survival rate of patients with GC was 35.9%from 2010 to 2014.The tumor immune mic...
关键词：LSD1 immune cells gastric cancer IMMUNOTHERAPY 
The demethylase FTO regulates the m6A modification and inflammation pathway in patients with cardiomyocytes after hypoxia-reoxygenation
《South China Journal of Cardiology》2024年第3期169-178,共10页ZHAO Hai-mei CHENG Hong JIAO Qi-hui 
supported by grants from Shenzhen Science and Technology Project(No.JCYJ20220531091817039)。
Background Myocardial ischemia-reperfusion injury is an important clinical problem.Hypoxia-reperfusion(HR)triggers a series of complex cellular reactions and pathological changes.In recent years,the role of N-6-methyl...
关键词：FTO m6A NF-k B IL-6 Anoxia and reoxygenation 
Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts
《BIOCELL》2024年第7期1105-1113,共9页CHUNLING LIANG JING CHEN XIAOJIE CHEN WEI YAN JIE YU 
Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identified in blood sequencing datasets from myocardial infarction patients and healthy controls.Myocardialfibrosis following my...
关键词：Cardiac fibroblasts FIBROSIS Myeloid cell receptor MIGRATION PROLIFERATION 
Beta-elemene inhibits the growth of KDM6A-null bladder cancer cells by suppressing the epithelial-mesenchymal transition
《Clinical Traditional Medicine and Pharmacology》2024年第2期15-24,共10页Ruonan Zhang Jiao Feng Yintao Zheng Qianru Zhu Bo Xiang Qibiao Wu Xinbing Sui 
various sources,including Zhejiang Provincial Natural Science Foundation of China(grant No.LQ20H160013,LQ21H160038,and LY23H160026);the Science and Technology Development Fund,Macao SAR(File No.:0098/2021/A2).
Background:Bladder cancer is a highly prevalent and lethal malignant tumor characterized by frequent mutations/deletions of lysine-specific demethylase 6A(KDM6A),which is suggested to be a key event in cancer progress...
关键词：Β-ELEMENE Lysine-specific demethylase 6A(KDM6A) Bladder cancer METASTASIS Epithelial-mesenchymal transition(EMT) 
Demethylase-assisted site-specific detection of N^(1)-methyladenosine in RNA
《Chinese Chemical Letters》2024年第5期397-401,共5页Jun Xiong Ke-Ke Chen Neng-Bin Xie Wei Chen Wen-Xuan Shao Tong-Tong Ji Si-Yu Yu Yu-Qi Feng Bi-Feng Yuan 
supported by the National Key R&D Program of China(Nos.2022YFC3400700 and 2022YFA0806600);the National Natural Science Foundation of China(Nos.22277093,22074110,21721005 and 22207090);the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(No.JCRCGW-2022-008);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(No.ZNJC202208)。
The dynamic RNA modifications have been viewed as new posttranscriptional regulator in modulating gene expression as well as in a broad range of physiological processes.N^(1)-methyladenosine(m^(1)A)is one of the most ...
关键词：N^(1)-methyladenosine RNA modification AlkB demethylase RNA epigenetics Quantitative real-time PCR Hepatocellular carcinoma 
A Label-Free Deoxyribozyme Sensor for m^(6)A Demethylase Activity Detection
《Chinese Journal of Chemistry》2024年第9期951-956,共6页Xiuyuan Wang Shusheng Yu Yuqiu He Fuan Wang Xiaoqing Liu 
supported by the Natural Science Foundation of Jiangsu Province(BK20221258);the National Natural Science Foundation of China(22274121 and 22274123).We thank Prof.Xiang Zhou at Wuhan University for CD measurement.
A label-free deoxyribozyme(DNAzyme)biosensor for m^(6) demethylase activity detection is developed.When demethylase FTO(Fat mass and obesity-associated protein),an important m^(6) demethylase of ALKBH demethylase fami...
关键词：DNAZYME Analytical methods BIOSENSING m^(6)A demethylation Fluorescence 
The emerging roles of lysine-specific demethylase 4A in cancer:Implications in tumorigenesis and therapeutic opportunities被引量：2
《Genes & Diseases》2024年第2期645-663,共19页Guanjun Yang Changyun Li Fan Tao Yanjun Liu Minghui Zhu Yu Du Chenjie Fei Qiusheng She Jiong Chen 
supported by the National Natural Science Foundation of China(No.31972821);the General Scientific Research Project of Education of Zhejiang Province,China(No.422204123);the Starting Research Fund of Ningbo University,Zhejiang,China(No.421912073).
Lysine-specific demethylase 4 A(KDM4A,also named JMJD2A,KIA0677,or JHDM3A)is a demethylase that can remove methyl groups from histones H3K9me2/3,H3K36me2/3,and H1.4K26me2/me3.Accumulating evidence suggests that KDM4A ...
关键词：Cancer therapy Drug resistance Histone demethylation JmjC domain KDM4A 
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